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hom

c. WT. o. hom. c. H46L. o.

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hom

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  1. c WT o hom c H46L o Supplementary Figure 4 The H46L mutation reduces KATP channel ATP sensitivity. (A) Meanrelationship between [ATP] (no Mg2+) and the fractional KATP conductance (G/Gc) for wild-type (WT) (closed circles, n=4), hetH46L (half-open circles, n=6) and homH46L (open circles, n=6) channels.(B)Representative Kir6.2/SUR1 and Kir6.2-H46L/SUR1 single-channel currents recorded at –60 mV. B A 1.0 0.8 0.6 G/G0 0.4 0.2 0.0 0.1 1 10 100 1000 [ATP], µmol/l

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