1 / 5

A. Antigen cluster 1

Supplementary Table 1. Cut-off values (pg/ml) for a positive antigen response in Uganda, The Gambia and South Africa.

tlara
Download Presentation

A. Antigen cluster 1

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Supplementary Table 1. Cut-off values (pg/ml) for a positive antigen response in Uganda, The Gambia and South Africa. The cut-off value for a positive IFN-g response, deduced separately for each African site, was calculated as the mean of the log-transformed negative control (NC) plus 2 standard deviations (SD). The limits of detection of the ELISA assays used (lowest point on standard curve) were 25pg/ml in Uganda and 15pg/ml in The Gambia and South Africa.

  2. Supplementary Table 2.Geometric means, medians, interquartile ranges, and percent positive responses to seven classical Mtb control antigens and PHA. aGeo Mean = geometric mean. bIQR = interquartile range. cN = number of participants tested. Ag85A and Ag85B protein antigens were combined to create a single stimulatory condition with each protein being tested at a final concentration of 10mg/ml.

  3. Supplementary Tables 3 A–C. Correlation matrices showing sites with Pearson’s correlation coefficient >= 0.6 for pair-wise comparisons of IFN-g responses to antigens within clusters 1 to 3. A. Antigen cluster 1

  4. B. Antigen cluster 2.

  5. C. Antigen cluster 3. Antigens were clustered together if they had pair-wise data available at all three African sites and were also included in the top 19 most frequently recognized antigens shown in Table 3. Sites with large associations (r > 0.6) between antigen pairs are shown to the right/above the diagonal aMAK = Uganda. bMRC = The Gambia. cSUN = South Africa. dM/M/S = Uganda, The Gambia and South Africa. Where MMS is shown a large association was observed at all three sites. If a correlation co-efficient > 0.6 was observed for more than one site, the smallest r value is shown.

More Related