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The Great Debate: should genetic or platelet function testing be used to individualize thienopyridine regimens

Objectives. Discuss the differential advantages and disadvantages of genetic testing versus platelet function testing to predict and assess the physiologic effect of clopidogrel on plateletsList the strengths and weaknesses of clinical trials exploring the use of platelet function testing to predic

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The Great Debate: should genetic or platelet function testing be used to individualize thienopyridine regimens

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    1. J. Erin Allender, PharmD, BCPS Cardiology Critical Care Clinical Specialist WakeMed Health and Hospitals August 2010 The Great Debate: should genetic or platelet function testing be used to individualize thienopyridine regimens?

    2. Objectives Discuss the differential advantages and disadvantages of genetic testing versus platelet function testing to predict and assess the physiologic effect of clopidogrel on platelets List the strengths and weaknesses of clinical trials exploring the use of platelet function testing to predict post-procedural ischemic events and bleeding and perioperative bleeding risk Describe how the results of ongoing clinical trials may be used to individualize thienopyridine regimens

    3. Financial disclosures and conflicts of interest None I will do all of this with (unfortunately) no financial ties.I will do all of this with (unfortunately) no financial ties.

    4. Background

    5. Clopidogrel pharmacokinetics

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