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Nucleic acid chemistry part 2 : chemical DNA synthesis

Nucleic acid chemistry part 2 : chemical DNA synthesis. Theoretical yield resulting from a number of reaction cycles, at indicated efficiencies. --------------------------------------------------- Number of cycles 90% 95% 99% 99.9% 5 59.0 77.4 95.1 99.5

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Nucleic acid chemistry part 2 : chemical DNA synthesis

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  1. Nucleic acid chemistrypart 2 : chemical DNA synthesis

  2. Theoretical yield resulting from a number of reaction cycles, at indicated efficiencies. --------------------------------------------------- Number of cycles 90% 95% 99% 99.9% 5 59.0 77.4 95.1 99.5 10 34.9 59.9 90.4 99.0 20 12.2 35.8 81.8 98.0 30 4.2 21.5 74.0 97.0 40 1.5 12.9 66.9 96.1 50 0.5 7.7 60.5 95.1 60 0.2 4.6 54.7 94.2 70 <0.1 2.8 49.5 93.2 80 - 1.7 44.8 92.3 90 - 1.0 40.5 91.4 100 - 0.6 36.6 90.5

  3. Triple helix formation with PNA (-derivatives): two extra chains (one of which in parallel orientation) (fig 1a) or with a so-called “clamp” (fig 1b)

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