Genetics Problems

1. Genetics Problems

2. Practice problem sheet

3. Problem 1

4. Problem 1solution

5. Problem 2

6. Problem 2solution

7. Problem 3 • In mice, a short-tailed mutant was discovered. When it was crossed to a normal long-tailed mouse, 4 offspring were short-tailed and 3 were long-tailed. Two short-tailed mice from the F1 generation were selected and crossed. They produced 8 short-tailed and 3 long-tailed mice. These genetic experiments were repeated three times with approximately the same results. Hypothesize the mode of inheritance and diagram the crosses.

8. Problem 4 • A rooster with gray feathers is mated with a hen of the same phenotype. Among their offspring, 15 chicks are gray, 6 are black, and 8 are white. • What is the simplest explanation for the inheritance of these colors in chickens? Incomplete Dominance • What offspring would you predict from mating a gray rooster and a black hen? Equal numbers of gray and black chicks

9. Problem 5 1/64 1/64 1/8 1/32

10. Homework Assignment

15. TR TR Tr Tr 6 Tall Pink 3 Tall Red 3 Tall White 2 Dwarf Pink 1 Dwarf Red 1 Dwarf White tR tR tr tr

25. More problems

26. The pedigree below traces inheritance of alkaptonuria. Affected individuals (colored in squares and circles) are unable to breakdown alkapton, which discolors urine and body tissues George Arlene Sandra Wilma Tom Sam Ann Michael Carla Tina Daniel Alan Christopher Is alkaptonuria a dominant of recessive trait? What are the genotypes of the individuals shown in this pedigree?

27. Carla is the Key! George Arlene Sandra Wilma Tom Sam Ann Michael Carla Tina Daniel Alan Christopher You can’t get a dominant trait from two recessive parents, so…Alkaptonuria must be recessive

28. Now we can fill in a lot of the genotypes! Everyone with the trait must be …aa aa George Arlene Sandra Wilma Tom Sam Ann Michael aa aa Carla aa Tina Daniel Alan Christopher

29. Everyone without the trait is …A_ A_ aa George Arlene A_ Sandra Wilma Tom Sam Ann Michael aa A_ aa A_ A_ Carla A_ aa Tina Daniel Alan A_ A_ A_ Christopher

30. George must be Aa to have fathered Tom and Wilma. Sam and Ann are Aa since their mom had to give them an a allele. Michael must be Aa to have fathered Carla. Aa aa George Arlene AA or Aa Sandra Wilma Tom Sam Ann Michael aa Aa aa Aa Aa Carla AA or Aa aa Tina Daniel Alan Aa Aa AA or Aa Christopher Daniel and Alan must be Aa to have been fathered by Tom (aa) We can not be sure of Sandra, Tina, or Christopher. Each of them may be either AA or Aa.

32. Key cross. Two recessives can’t have both recessives and dominants, so…Polydactyly is Dominant

33. Can’t be sex-linked. Since polydactyly is dominant. A recessive mother could not have affected sons by a PY father Key cross. Two recessives can’t have both recessives and dominants, so…Polydactyly is Dominant

37. RR X Rr R r R R

38. Still more problems

39. My sexual partner has type A blood. I have type AB. She has a child with type O blood. Can this child be mine?

40. My sexual partner has type A blood. I have type B. She has a child with type O blood. Can this child be mine?

41. Kate and Bob want children. Kate’s dad had hemophilia (an X-linked recessive disorder). Kate’s brother Ted has hemophilia. She wants to know the odds of her having a child with hemophilia. What do you tell her?

42. X-linked Problem a • A female MendAlien, Marge, with no ears (the normal condition) and whose male parent had pointed ears pairs with a male MendAlien with no ears and whose male parent also had pointed ears. • Using e for the pointed ear allele and E for the normal no-ear allele, diagram the cross and give the proportions of the phenotypes in the offspring that will have ears. (Give your answer separately for males and females)

43. X-linked Problem a • A female MendAlien, Marge, with no ears (the normal condition) and whose male parent had pointed ears pairs with a male MendAlien with no ears and whose male parent also had pointed ears. • Using e for the pointed ear allele and E for the normal no-ear allele, diagram the cross and give the proportions of the phenotypes in the offspring that will have ears . (Give your answer separately for males and females) This picture is wrong! Can you spot the problem with the drawings?

44. X-linked Problem b • Assume, instead, that the female MendAlien, in part a, pairs with a male MendAlien with pointed ears as follows: • Diagram the cross, and give the proportions of the phenotypes in the offspring. (give your answer separately for males and females)

45. X-linked Problem b • Assume, instead, that the female MendAlien, in part a, pairs with a male MendAlien with pointed ears. • Diagram the cross, and give the proportions of the phenotypes in the offspring. (give your answer separately for males and females)

46. Ear lobes in people may be free hanging or completely attached to the side of the face. This is determined by a single gene locus; the free hanging allele, E, is dominant and the attached allele (e) is recessive. A. A person has the heterozygous genotype Ee. With respect to this gene locus, how many kinds of gametes, eggs or sperm, will this person produce? What will the percent or frequency of each kind of gamete be out of the total possible? B. A man and a woman who are both heterozygous for ear lobe condition have children. What is the probability that a child will have free ear lobes? What is the probability that a child will have attached ear lobes? C. A man with attached ear lobes and a woman with free ear lobes have three children; two have free ear lobes and one has attached ear lobes. • What is the man’s genotype? • What is the woman’s genotype? • What are the genotypes of the three children?

47. Ear lobes in people may be free hanging or completely attached to the side of the face. This is determined by a single gene locus; the free hanging allele, E, is dominant and the attached allele (e) is recessive. A. A person has the heterozygous genotype Ee. With respect to this gene locus, how many kinds of gametes, eggs or sperm, will this person produce? What will the percent or frequency of each kind of gamete be out of the total possible? Two types of gametes…50% E and 50% e B. A man and a woman who are both heterozygous for ear lobe condition have children. What is the probability that a child will have free ear lobes? What is the probability that a child will have attached ear lobes? C. A man with attached ear lobes and a woman with free ear lobes have three children; two have free ear lobes and one has attached ear lobes. • What is the man’s genotype? • What is the woman’s genotype? • What are the genotypes of the three children?

48. Ear lobes in people may be free hanging or completely attached to the side of the face. This is determined by a single gene locus; the free hanging allele, E, is dominant and the attached allele (e) is recessive. A. A person has the heterozygous genotype Ee. With respect to this gene locus, how many kinds of gametes, eggs or sperm, will this person produce? What will the percent or frequency of each kind of gamete be out of the total possible? Two types of gametes…50% E and 50% e B. A man and a woman who are both heterozygous for ear lobe condition have children. What is the probability that a child will have free ear lobes? What is the probability that a child will have attached ear lobes? Cross is Ee X Ee (children will be 3 hanging:1 attached) C. A man with attached ear lobes and a woman with free ear lobes have three children; two have free ear lobes and one has attached ear lobes. • What is the man’s genotype? • What is the woman’s genotype? • What are the genotypes of the three children?

49. Ear lobes in people may be free hanging or completely attached to the side of the face. This is determined by a single gene locus; the free hanging allele, E, is dominant and the attached allele (e) is recessive. A. A person has the heterozygous genotype Ee. With respect to this gene locus, how many kinds of gametes, eggs or sperm, will this person produce? What will the percent or frequency of each kind of gamete be out of the total possible? Two types of gametes…50% E and 50% e B. A man and a woman who are both heterozygous for ear lobe condition have children. What is the probability that a child will have free ear lobes? What is the probability that a child will have attached ear lobes? Cross is Ee X Ee (children will be 3 hanging:1 attached) C. A man with attached ear lobes and a woman with free ear lobes have three children; two have free ear lobes and one has attached ear lobes. ee X E_  2E_ and 1 ee • What is the man’s genotype? ee • What is the woman’s genotype? Ee • What are the genotypes of the three children? Ee and Ee and ee

50. Remember Labradors Genes often interact with one another. The term epistasis is applied to cases in which one gene alters the expression of another gene that is independently inherited. In Labrador retriever dogs one gene locus is involved with production of melanin pigment: B (black) and b (brown) are its two alleles. Another gene locus determines whether the melanin produced is actually deposited in individual hairs as they grow (E) or not deposited (e). Any dog with at least one dominant allele B and one dominant allele E will be a black Labrador. A dog with the homozygous recessive bb and at least one dominant E will be a lighter, chocolate Labrador. If a dog has the homozygous ee genotype it will be a yellow Labrador, regardless of the alleles at the pigment locus.