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Michael Birrer, PI, Director, Gynecologic Medical Oncology, MGH

The Genomic, Epigenomic , and Quality of Life Characteristics of Long-Term Survivors of Ovarian Cancer: A Department of Defense-Funded Project. Michael Birrer, PI, Director, Gynecologic Medical Oncology, MGH Lari Wenzel, Co-PI, Prof. of Medicine, University of California, Irvine

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Michael Birrer, PI, Director, Gynecologic Medical Oncology, MGH

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  1. The Genomic, Epigenomic, and Quality of Life Characteristics ofLong-Term Survivors of Ovarian Cancer:ADepartment of Defense-Funded Project Michael Birrer, PI, Director, Gynecologic Medical Oncology, MGH Lari Wenzel, Co-PI, Prof. of Medicine, University of California, Irvine longtermsurvivors@gmail.com Finding the Key to Long-Term Survival for All Women

  2. Ovarian CancerA Deadly Disease with Hope 23,000 women in the USA each year are diagnosed with Ovarian Cancer 80% have an advanced stage cancer (Stage III or IV) 16,000 women in USA die of Ovarian Cancer each year But 10% Do Survive Long Term ! Finding the Key to Long-Term Survival for All Women

  3. Who Are We? Finding the Key to Long-Term Survival for All Women

  4. Why Am I Still Alive? What is different about long-term (10+ years) survivors? Is it something about the patient or the tumor or both? What are the long-term consequences of the diagnosis and treatment of ovarian cancer? Finding the Key to Long-Term Survival for All Women

  5. Goals PROs QOL Finding the Key to Long-Term Survival for All Women

  6. A Holistic Approach Study • Identify Stage 3 or 4 Ovarian Cancer Long-Term Survivors • Collect Tissues and Characterize • Molecular markers (genetic, biochemical, immunology) • PatientQuality of Life • Identify a Link Between 1 and 2 • Establish Clinical Tools and Targeted Therapies Finding the Key to Long-Term Survival for All Women

  7. Consortium Structure PATIENTS Scientific Advisory Board Chair: Phil DiSaia Advocate Advisory Board Chair: Mary Scroggins Coordinating Center: MGH PI: Michael J. Birrer Co-PI: Lari Wenzel, Ph.D. Scientific Committee Research Sites GOG Clinical Trials 39 Institutions GOG Tissue Bank 39 Institutions Genomic, Biologic, Psychosocial Data Collection Clinical Conclusions: Tools and Targets

  8. The Gynecology Oncology Group Tissue Repository Patients Database 50 Principal Centers and 187 Participating Hospitals Multi-Modality Group with Over 2100 Participants GOG Clinical Trials Brought ALL the Major Improvements in the Management of Ovarian Cancer Finding the Key to Long-Term Survival for All Women

  9. The Advocate Advisory Board Ensures the project remains patient- and goal-focused, scientifically sound, and clinically relevant Finding the Key to Long-Term Survival for All Women

  10. What Is Needed? Identification of Long-Term Survivors (10+ years) with Advanced Stage Ovarian Cancer (Stage III and IV only) Paraffin-Embedded Tumor Specimen from ANY Biopsy or Surgery “Quality of Life”, Toxicity and Medical Treatment Reports Finding the Key to Long-Term Survival for All Women

  11. Without You…….Nothing Can Happen! Please Contact The Long-Term Survivors Group: longtermsurvivors@gmail.com Finding the Key to Long-Term Survival for All Women

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