Introduction

1. Treatment & prevention of side effects induced by oral, high-dose magnesium therapy of mental illnesses George A. Eby and Karen L. Eby George Eby Research Institute, 14909-C Fitzhugh Road, Austin, Texas 78736 USA Email george.eby@george-eby-research.com Discussion/Evaluation A number of clinical and basic scientific studies on the effects of magnesium in mental health have been reported: • 1921: Weston first reported that magnesium sulfate injections terminated agitated depression within a few hours. Magnesium sulfate (10% elemental magnesium) was injected in doses of one to two CCs of a 25% or 50% solution resulting in nearly all of his fifty patients relaxing and sleeping from 4 to 6 hours. • 2001:Papadopol et al. showed that stress from orphanage living drove down intracellular magnesium so severely that orphans lost much of their IQ. Magnesium deficit caused a number of neuropsychological disorders including, agitation, anxiety, depression, irritability, weakness, fatigue, confusion, • asthenia, sleeplessness, headache, convulsive and nervous attacks, delirium, hallucinations and hyperexcitability. • 2006: Eby and Eby reviewed the literature and suggested that high-dose magnesium treatment (800 to 1200 mg /day) was effective for depression, traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, drug abuse, memory loss and IQ loss. Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having been previously documented. The possibility that magnesium deficiency is the cause of most major depression and related mental health problems including IQ loss and addiction is enormously important to public health and is recommended for immediate further study. • 2006: Enya showed that depression could be immediately relieved by IV injection of magnesium sulfate, while oral magnesium oxide was not effective. • 2006: Eby demonstrated that magnesium throat lozenges were effective as rescue treatment for allergy-induced asthma in adults, producing rescue in minutes. However, a common cold treated with a single 100 mg magnesium (magnesium chloride) throat lozenge producing +100 mM salivary concentration lasted two months and was very severe. • 2009: Eby hypothesized that magnesium throat lozenges would severely worsen rhinovirus-induced asthma - perhaps fatally - since 30 mM magnesium chloride was shown in the 60’s to increase the release of rhinoviruses by 8- to 310-fold. • NOTE: Although magnesium over-dose is well known to produce diarrhea, very little was found concerning biologics-induced side effects of high-dose, oral magnesium treatment. However, our uncontrolled observations and the reports from others have convinced us that more consideration of its pro-herpes, pro-Candida albicans and pro-rhinovirus potential is needed. • For example - anecdotally: • Treatment of active genital herpes infections with +100 mM magnesium chloride greatly worsened infections. • Oral herpes was very greatly worsened upon use of +100 mM magnesium chloride facial treatment. • Daily use of magnesium chloride throat lozenges resulted in severe, chronic rhinosinusitis, apparently from a Candida albicans infection. • Diarrhea and intestinal distress from high-dose magnesium may be caused by overgrowth of intestinal Candidiasis as well as the well-known attraction of a large number of water molecules by magnesium. • A single magnesium throat lozenge worsened a common cold which lasted over two months and was only modestly treatable with zinc lozenges. Very Brief Overview of Literature Results: Oral magnesium-worsened Candidiasis responds slowly to treatment. Viral infections worsened by magnesium respond slowly to zinc treatment. Important Figures from the Literature Conclusions:Prevention and management of biologics-induced side effects insures that beneficial magnesium compounds will remain safe and effective broad-spectrum mental health treatments. Medical means of rapidly increasing brain magnesium through use of IV drips, injections, intracranial, intrathecal, rectal and transdermal administration (usually magnesium sulfate or chloride) need to be developed to prevent biologics–induced oral side effects of magnesium, at least in the beginning of treatment. Objectives: To maintain efficacy, prevent side effects, treat or prevent exponential growth stimulating effect on Candida albicans in the upper and lower gastrointestinal tract and prevent worsening of rhinovirus and herpes simplex viral infections. Introduction High-dose (600 to 1200 mg/day) oral magnesium treatment is effective in rapidly terminating depression, habituations, loss of intelligence, attention and memory, treating other neuroses including anxiety, hyper-emotionality, fatigue, panic, headaches, migraines, insomnia and preventing suicide. Concentrated magnesium solutions without calcium exponentially worsen Candida albicans infections of the upper and lower gastrointestinal tract, increase rhinovirus release up to 310-fold at 30 mM concentration and greatly increase herpes-simplex viral count. Although immediately effective in treating adult allergy-induced asthma, magnesium throat lozenges greatly worsen rhinoviral common colds. Since rhinoviruses are a primary source of childhood asthma, use of magnesium throat lozenges in pediatric (or adult) asthmatics could be fatal, and they will also greatly worsen herpes simplex infections. Magnesium oxide is not brain bioavailable, and magnesium aspartate and glutamate are neurotoxic. • References • Weston PG. Magnesium as a sedative. Am J Psychiat. 1921;78:637–8. • Papadopol V, Tuchendria E, Palamara I. Magnesium and some psychological features in two groups of pupils (magnesium and psychic features). Magnes Res 2001;14 (1/2):27–32. • Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-70. • Eby GA, Eby KL. Magnesium for treatment-resistant depression: A review and hypothesis. 2009 (pending). • Eby GA. Rescue treatment and prevention of asthma using magnesium throat lozenges: Hypothesis for a mouth-lung biologically closed electric circuit. Med Hypotheses. 2006;67(5):1136-41. • Eby GA. Hypothesis for risk of death or serious sequela from asthmatic use of magnesium throat lozenges due to 8- to 310-fold rhinovirus release increase by concentrated magnesium. Medical Hypotheses. 2009. • Enya M, Kanoh Y, Mune T, et al. Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman's syndrome. Intern Med. 2004;43(5):410-4. • Holmes AR, Cannon RD, Shepherd MG. Effect of calcium ion uptake on Candida albicans morphology. FEMS Microbiol Lett. 1991;61:187-93. • Fiala M, Kenny GE. Effect of magnesium on replication of rhinovirus HGP. J Virol 1967;1:489–93. • Fiala M. Plaque formation by 55 rhinovirus serotypes. Appl Microbiol 1968;16:1445–50. • Eby GA. Zinc lozenges: cold cure or candy? Solution chemistry determinations. Biosci Rep 2004;24(1):23–39. Methods:Only use beneficial magnesium compounds. Treatment of oral magnesium-induced Candidiasis includes therapeutic doses of calcium (which may immediately worsen depression), biotin, indole-3-carbinol, inulin, acid-resistant probiotics (Bacillus coagulans), anti-diarrheal agents and antifungals. Zinc acetate throat lozenges (18 mg ionic zinc) may shorten common colds and eliminate oral herpes infections worsened by magnesium. Strong (100 mM) topical ionic zinc gluconate solutions may effectively treat herpes simplex skin lesions worsened by magnesium. Very little has been published concerning the biologics-induced side effects of high-dose, oral magnesium treatment. However, our uncontrolled anecdotal observations and anecdotal reports of others using high-dose magnesium to treat mental illness have convinced us that more consideration of the pro-herpes, pro-Candida albicans and pro-rhinovirus potential is needed, with special consideration of its adverse effects on the intestinal tract. If high-dose magnesium is to be optimally useful in treating mental illness, it may need to be administered using parenteral administration