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Inhibitory Role of ICAM-2 in Neuroblastoma Tumor Growth: Insights from In Vitro and In Vivo Models

This study, illustrated in Supplementary Figure S2 by Feduska et al., reveals how elevated ICAM-2 expression in NB-1691 neuroblastoma cells inhibits colony growth in soft agar and suppresses disseminated tumor growth in a metastatic neuroblastoma model. Results showed that ICAM-2 WT significantly reduced anchorage-independent growth of NB-1691 cells in vitro, as confirmed by immunoblots. Furthermore, mice injected with NB-1691 cells upregulated with ICAM-2 WT exhibited extended survival compared to those with low ICAM-2 expression. Survival analysis was performed using the log-rank test on Kaplan-Meier plots generated by GraphPad Prism 5 software (P=0.0155*).

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Inhibitory Role of ICAM-2 in Neuroblastoma Tumor Growth: Insights from In Vitro and In Vivo Models

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  1. Supplementary FigureS2 (Feduska et al.) A B C NB-1691 Control WT 64 ICAM-2 51 97 α-actinin FigureS2. Elevated ICAM-2 expression in NB-1691 NB cells inhibited colony growth in soft agar and inhibited disseminated tumor growth in an in vivo model of metastatic neuroblastoma. (A) Analysis by t-test demonstrated that ICAM-2 WT suppressed anchorage-independent growth of NB-1691 cells in vitro (P<0.0001). (B) Immunoblots confirmed that transfected NB-1691 cells expressed readily detectable levels of ICAM-2 WT. (C) Mice injected i.v. with NB-1691 cells transfected to upregulate expression of ICAM-2 WT survived longer than mice receiving cells expressing low detectable ICAM-2. Kaplan-Meier survival plots were analyzed by log-rank test using GraphPad Prism 5 software (P=0.0155*).

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