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SYMPATHOMIMETICS

SYMPATHOMIMETICS. Classification: A- According to the source: Natural; NE, EP, DA Synthetic; isoproternol , ephedrine, amphetamine B- chemically: Catecholamines ; NE, EP, DA and isoproternol Non catecholamines ; ephedrine, amphetamine, tyramine. α & β Receptor Agonist

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SYMPATHOMIMETICS

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  1. SYMPATHOMIMETICS Classification: A- According to the source: • Natural; NE, EP, DA • Synthetic; isoproternol, ephedrine, amphetamine B- chemically: • Catecholamines; NE, EP, DA and isoproternol • Non catecholamines; ephedrine, amphetamine, tyramine

  2. α &β • Receptor • Agonist • Antagonist • (blockers) • D receptor • Agonist • IN DIRECT(MIXED) ACTING drugs • Agonist • ( adrenergic) • Increase release of agonist(NE) • Work on receptor as agonist (NE) • Antagonist • (anitadrenergic) • False NE β receptor Agonist Antagonist (blockers) α receptor Agonist Selective α2: clonidine Non selective α 1, α2: Phenylephrine Antagonist (blockers) Selective: α1=parzosin, Tamsulosin α2= yohimbine Non selctiveα 1, α2: Phenoxybenzamine phentolamine >illegal

  3. α1 α2

  4. β1 β2

  5. Activation of β3 receptors in fat cells leads to increased lipolysis.

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