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cPML

Supp. Fig.3. c. a. Smad3. cPML binding. Smad3 binding. cPML. MH1. Linker. MH2. R. B1-B2. C-C. C-terminal. +. +. 1. 425. 1. MH1. Linker. +. B1-B2. C-C. C-terminal. +. 1. 270. 98. -. Linker. MH2. _. C-C. C-terminal. 425. 170. 228. 475. MH2. -. 270. 425. b.

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cPML

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  1. Supp. Fig.3 c a Smad3 cPML binding Smad3 binding cPML MH1 Linker MH2 R B1-B2 C-C C-terminal + + 1 425 1 MH1 Linker + B1-B2 C-C C-terminal + 1 270 98 - Linker MH2 _ C-C C-terminal 425 170 228 475 MH2 - 270 425 b d Input IP:PML IP: Xpress Smad3 Smad3 WB: Flag Smad3 1-270 WB:Xpress Smad3 170-425 cPML WB: Xpress cPML 98-475 Smad3 270-425 cPML 228-475 cPML WB:PML Flag-Smad3 Input - - Xpress-Smad3 + - + - - + - + - - Flag-Smad3 - + + + + Xpress-Smad3 170-425 - - - - - - - - - - + + Xpress-cPML - + + - - - - Xpress-Smad3 270-425 - - - + - - - - + - Xpress-cPML 98-475 - - - + - - - Xpress-Smad3 1-270 - - - - + - - - - + Xpress-cPML 228-475 - - - - + cPML - + + + + - + + + + + + TGF-1 - - + - -

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