1 / 12

Understanding Reproductive Aging: Insights into Ovarian Function and Menopause

Reproductive aging is a continuous process starting before birth, with ovarian dysfunction occurring years before menopause. Perimenopause signifies a critical threshold of non-growing follicles (NGFs) depletion. This research explores a new power model describing NGF depletion, proposing a simpler and more accurate approach than previous exponential and biphasic models. The study, involving human ovaries from elective surgeries and tissue banks, reveals that 84% of NGF count variability is age-related. Clinical markers could enhance predictive accuracy.

trumbo
Download Presentation

Understanding Reproductive Aging: Insights into Ovarian Function and Menopause

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 2008/08/ 何積泓

  2. Reproductive Aging • A continuous process begins prior to birth • The depletion of non-growing follicles (NGFs) • Ovarian dysfunction occurs many years prior to menopause • Perimenopause: the number of remaining ovarian NGFs has dropped below a critical threshold

  3. Menopause • Average 51 ± 8 years • Initial endowment of NGFs • The rate of NGF depletion • A model to better describe NGF depletion • Previous model: the decay rate is exponential and biphasic (4 studies, n = 6 ~ 52)

  4. Human ovaries • Elective unilateral or bilateral oophorectomy (n = 45) • Organ donation agencies or national tissue bank (n = 77) • Exclusion: chemotherapy, radiation, ovarian surgery, ovarian pathology, cyst > 2cm diameter

  5. Linear model, R2 = 0.50, 3.83M NGFs at birth, 2,290 NGFs at 51 y/o

  6. Exponential model, R2 = 0.46, 2.75M NGFs at birth, 3,881 NGFs at 51 y/o

  7. Biphasic exponential model, 1.15M NGFs at birth, 1,071 NGFs at 51 y/o

  8. Power model, log(NGF#)=a(age)b+c, R2=0.84 0.52M NGFs at birth, 758 NGFs at 51 y/o

  9. Discussion • Previous exponential and biphasic model is unrealistic • Power model is simpler and better • The NGF depletion is constantly accelerating • 84% variability in NGF count is explained by age • Other clinical markers may improve the predictive power

More Related