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EX. 20 Antibiotic Disk Sensitivity. Antibiotics . Naturally occurring compounds produced by bacteria and or fungi, that kill or inhibit other microbes Many Antibiotics are produced by 2 Genera of Bacteria Streptomyces Bacillus 1 Fungal Genus Penicillium. Common Antibiotics.
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Antibiotics • Naturally occurring compounds produced by bacteria and or fungi, that kill or inhibit other microbes • Many Antibiotics are produced by • 2 Genera of Bacteria • Streptomyces • Bacillus • 1 Fungal Genus • Penicillium
Common Antibiotics • Stretomycin – Streptomyces • Bacitracin - Bacillus • Penicillin - Penicillium • Protein synthesis • 70S Ribosme • Cell Wall synthesis • Cell Wall synthesis
Selective toxicity • The antibiotic must harm the pathogen without harming the host cell • Antibiotics do this by: • 1. Attacking the 70S Ribosome (Protein synthesis) • 2. Attacking the Cell Wall
MIC • Minimum Inhibitory Concentration • Least amount of an antibiotic that will inhibit the growth of a microbe
MRSA • Methicillin Resistant Staphylococcus aureus • Vancomycin • Last line of defense against MRSA – which has led to • VRE • Vancomycin Resistant Enterococci