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Comment gérer un traitement anticoagulant au quotidien. Stephane EDERHY Service de cardiologie Hôpital SAINT ANTOINE. Fibrillation Atriale. Quel risque ?. Cardiovascular morbidity and mortality associated with Atrial Fibrillation. Kirchoff ESC Guidelines 2016.
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Comment gérer un traitement anticoagulant au quotidien Stephane EDERHY Service de cardiologie Hôpital SAINT ANTOINE
Fibrillation Atriale Quel risque ?
Cardiovascularmorbidity and mortalityassociatedwith Atrial Fibrillation Kirchoff ESC Guidelines 2016
Conditions associatedwith AF Kirchoff ESC Guidelines 2016
Fibrillation Atriale Comment évaluer le risque thromboembolique ?
Clinicalriskfactors for stroke, TIA and systemicembolism Kirchoff ESC Guidelines 2016
Fibrillation Atriale Comment évaluer le risque hémorragique ?
Modifiable and non-modifiable riskfactors for bleeding in anticoagulated patients based on bleedingrisk scores
Fibrillation Atriale Quel traitement ?
Stroke prevention in Atrial Fibrillation Kirchoff ESC Guidelines 2016
Fibrillation Atriale Comment prescrire ? Interactions médicamenteuses Fonction rénale
P-GP / CYP Drug-Drug Interactions Gastro intestinal tract CYP3A4 P-gp P-gp CYP2J BCRP CYP3A4 P-gp bile Renal Tubular Cells Enterocyte Hepatocyte
List of substrates,inhibitors and inducers of CYP3A4 and P-glycoprotein Heidbuchel Europace 2013 ;15:625-651
Fibrillation Atriale Anticoagulant et Fonction renale
Dose adjustment for NOACs as evaluated in the PHASE III trials Kirchoff ESC Guidelines 2016
Risque thrombo embolique et Adaptation de dose et fonction rénale
Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction Yao J Am CollCardiol 2017;69:2779–90
Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction Yao J Am CollCardiol 2017;69:2779–90
Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction OVERDOSING UNDERDOSING Yao J Am CollCardiol 2017;69:2779–90
Fibrillation Atriale Anticoagulant et Valvulopathie
Non–Vitamin K AntagonistOral Anticoagulants in Patients With Atrial Fibrillation and Valvular Heart Disease Renda J Am CollCardiol 2017 ; 69 : 1363 - 71
Fibrillation Atriale Relais ?
Management of direct oral anticoagulants in patients undergoing elective surgeries and invasive procedures: Low hemorrhagic risk procedureUpdated guidelines from the French Working Group on Perioperative Hemostasis Albaladejo P AnaesthCritCare Pain Med 2017 ;36 : 73–76
Atrial Fibrillation Hémorragie active
Fibrillation Atriale Maladie coronaire
European Heart Rhythm association proposal for a universal NOAC anticoagulation card
European Heart Rhythm association proposal for a universal NOAC anticoagulation card
Practical SuggestionsMonitoring 1- Stratification du risque 2- Interaction medicamenteuse 3- Fonction rénale 4- Education thérapeutique
List of substrates,inhibitors and inducers of CYP3A4 and P-glycoprotein Heidbuchel Europace 2013 ;15:625-651
RivaroxabanP-gp/CYP Gong Can J Cardiol 2013 ;29:S24
Apixaban Gong Can J Cardiol 2013 ;29:S24
eCrCL estimated based on Cockroft-Gault equation Exclusion criteriarelated to CKD Dose Adjustmentrelated to CKD