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Fitzpatrick Institute for Photonics Duke University

The Fitzpatrick Institute for Photonics at Duke University focuses on biophotonics, nano and micro systems, quantum optics, and more. They develop competencies in nanophotonics, systems modeling, and novel spectroscopies for applications such as cancer diagnostics and single-cell analysis.

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Fitzpatrick Institute for Photonics Duke University

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  1. Fitzpatrick Institute for PhotonicsDuke University Tuan Vo-Dinh

  2. Fitzpatrick Institute for Photonics Duke University Physical Facilities Fitzpatrick Center for Interdisciplinary Engineering, Medicine, and Applied Science “FCIEMAS” $100M, 300,000-sqft Facilities Dedication: November, 2004 Fitzpatrick Institute for Photonics (FIP) 120,000-sqft Facility 65 Faculty and Research Groups 20 + Departments at Duke

  3. Maintain Excellence in Current Core Competencies • Biophotonics • Nano and Micro Systems • Quantum Optics & Information Photonics • Photonic Materials • Advanced Photonic Systems Strategic focus on target applications based on competencies

  4. Single Cell Nanoprobe Develop New Competencies inSelected Target Areas • Nanophotonics • Systems Modeling & Theory and Data Treatment • Novel Spectroscopies

  5. Optical Coherence TomographyJoseph Izatt Clinical Systems at Duke Medical Center Company Spin-Off: Optigen, Inc

  6. Breast Biopsy NeedleNimmi Ramanujam

  7. Fourier Domain Low Coherence Interferometry LCI (fLCI): Spectral Characterization of Nuclear MorphologyAdam Wax • Can determine longitudinal diameter of nucleus of cells in vitro • Comparison of fLCI with confocal microscopy shows good accuracy R.N. Graf and A. Wax,Opt. Express 13, 4693(2005).

  8. Minimally Invasive In Vivo Cancer Diagnostics Optics Nitrogen Laser Dye Module Endoscope Multi- channel Detector Poly- chromator Bifurcated Optical Fiber PC Clinical Trials: Over 100 patients 98% Sensitivity; 95% Specificity

  9. Metal layer Support Nanoparticle Layer Halfshell Array as SERS Substrates • Nanoparticle-based Substrate Parameters: • Nanoparticle material (e.g. alumina, titanium dioxide, polystyrene, fumed silica) • Nanoparticle size (e.g. 50 nm- 500 nm) • Metal (e.g. silver, gold, copper) • Metal thickness (e.g. 50-100 nm) Scanning electron micrograph of silver-coated polystyrene microspheres

  10. Raman Label Metal Particle Bioreceptor Surface-Enhanced Raman Scattering (SERS) Nanoparticle Probes • Targeting molecules to be used will include: • Specific bioreceptors • Antibodies • DNA constructs that are complementary to a mRNA target sequence • Enzymes • Advantages of SERS-based labels • Comparable sensitivity to fluorescence • Resistance to photobleaching and quenching • Enhanced spectral multiplexing (sharp lines minimal overlap)

  11. Nanosensor for Single-Cell Analysis Single Cell Caspase-7 Mitochondria Caspase-9 Cytochrome c Nanosensor Procaspase-9 Apoptosome Apap-1 Fig. 8

  12. The Biochip Technology • 2-D array of independently operating photodiodes • On-board signal amplification and data treatment • CMOS-based microelectronics integrated onto a single platform • Coupled to compact sampling system ADVANTAGES: • Compact design • Microscale sampling capability • Low power consumption • Multiple assays possible on single platform • Increased throughput • Cost effectiveness

  13. Fitzpatrick Institute for Photonics Bridging the Gap: From the Nano World to Field Devices Integrated Nano and Micro Systems • Traditional Approach • High Cost, Low Volume, Niche • Separate Component Packaging • Next Generation • Low Cost, High Volume, Pervasive • Integrated/Embedded OE Packaging • Take OE packaging from discrete to integrated (emulating the IC revolution in the last 50 years) • Making tabletop systems into ladybug size Nan Marie Jokerst, FIP

  14. Nanoparticle Plasmonics for Molecular DetectionA A Lazarides, Duke University On/ off states of a chip fragment Objective: Dsign and demonstrate reconfigurable plasmonic assemblies for use as sensors in optoelectronic detection systems and in cells Detection and Transduction: • Thermodynamic principles of soft matter assembly can be used to design self-assembling biomolecule-linked assemblies • Reconfigurable DNA nanostructures can be designed to control interparticle separation and coupling • Plasmonic sensors can be be integrated onto optoelectronic substrates or used as portable signallers in fluid biosamplese or cells BIomolecule-driven reconfiguration using DNA nanostructures Single assembly spectroscopy with Jack Mock and David Smith Spectrum predicted from structure with T H LaBean Microscopy Spectroscopy

  15. Self-Assembling DNA NanostructuresThom LaBean, FIP, Duke University • Biomolecular self-assembly. • DNA building blocks. • Organization of other materials. • Photonic applications. • Future directions and applications. 500 x 500 nm

  16. Negative e at Optical WavelengthsCloaking MaterialsDavid Smith, Duke University • Properties of Plasmons: • Surface modes • Spatial variation of optical wavelengths on a scale <<l. • Large local field enhancements • Large local density of states • Contributes to SERS and SERRs phenomena • Fast (fs) time scales

  17. Technologies for Integrated Nano- and Micro-Systems • Miniaturized systems containing: • Nanoprobes and microsensors • Control and signal processing electronics • Micro and nanofluidics • Wireless alarm/data transmission • Microactuators • Integrate all of these components into a single mini-micropackage • Patch, Probe, Stamp-sized • Operates on a coin battery • Continuous monitoring with pre-set alarm conditions and sensing information OR • One shot sensing (disposable probes) • Wireless data download

  18. Fitzpatrick Institute for Photonics Faculty (March 28, 2006) Fitzpatrick Institute for Photonics Faculty (April 7, 2006) Fitzpatrick Institute for Photonics Tuan Vo-Dinh, Director Biophotonics Izatt, Joseph, Program Director Brady, David Johnson, G. Allan Provenzale, James Ramanujam, Nimmi Shang, Allan Vo-Dinh, Tuan Warren, Warren* Wax, Adam Advanced Photonic Systems Reichert, William, Program Director Brady, Rachael Chakrabarty, Krish Johnson, Kristina Edwards, Glenn Guenther, Bob Massoud, Hisham* Ozev, Sule Nanophotonics Leong, Kam, Program Director Chikolti, Asutosh Lazarides, Anne Liu, Jie Smith, David* Vo-Dinh, Tuan* Wax, Adam* Yoshie, Tomoyuki Nano/Micro Systems Jokerst, Nan , Program Director Brooke, Martin Fair, Richard LaBean, Thomas Massoud, Hisham Tian, Jingdong Yoshie, Tomoyuki* Systems Modeling, Theory & Data Treatment Yang, Weitao, Program Director Beratan, David, Dwyer, Chris Krolik, Jeffrey Liu, Qing Pitsianis, Nikos Sun, Xiaobai Venakides, Stephanos Quantum Optics and Information Photonics Gauthier, Daniel, Program Director Baranger, Harold Kim, Jungsang Thomas, John Warren, Warren* Photonic Materials Smith, David, Program Director Brown, April Cummer, Steve Glass, Jeff Jokerst, Nan* Massoud, Hisham* Stiff-Roberts, Adrienne Novel Spectroscopies Warren, Warren, Program Director Brady, David Izatt, Joseph* Palmer, Richard Simon, John Vo-Dinh, Tuan* Wax, Adam*

  19. OPTO Nanosystems & Nanophotonics Biophotonics Information Photonics & Quantum Optics A Global Photonics VisionAn Initiative at the New Frontiersof Science and Technology NANO BIO INFO

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