1 / 3

Facility Status and Highlights of the AMRIS MRI/S Program

NHMFL development cores in HTS NMR probes, novel contrast agents for use at high fields, and microimaging are now leveraged by NIH funding R01 to fund 1.5-mm HTS 13 C-optimized probe construction began in fall 2009

udell
Download Presentation

Facility Status and Highlights of the AMRIS MRI/S Program

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. NHMFL development cores in HTS NMR probes, novel contrast agents for use at high fields, and microimaging are now leveraged by NIH funding • R01 to fund 1.5-mm HTS 13C-optimized probe construction began in fall 2009 • R01 application for development of MR Microscopy at the cellular level is at 2nd percentile • U54 to study failed regeneration in the muscular dystrophies using novel contrast approaches is one of three anticipated funded centers in the country. • Three of seven instruments in the facility upgraded/will receive upgrade in 2010 and early 2011. This is a $1.4M investment in the facility with $0.3M from NHMFL funding. • New partnership with UF Chemistry and CTSI to develop center for metabolomics integrating 1.5-mm HTS 13C-optimized probe, developed with Agilent, on a new 600 MHz instrument. This instrument, a $800k investment with $100k from the NHMFL, will be part of the NHMFL external user program. • Hired a PhD level Staff Scientist for Animal Imaging to support UF and NHMFL external user programs. • Partnered with high B/T facility on successful ARI-R2 proposal to revitalize the UF helium liquefaction and recovery system. Facility Status and Highlights of the AMRIS MRI/S Program as of summer 2010, mid-point in current award period

  2. Science Highlights of the AMRIS MRI/S Program • First MRI microscopy of mammalian neurons and subcellular structures • Two cover articles in NeuroImage • Imaging with direct histological characterization of nucleoli in frog ova • Development of stronger gradients and perfusion probe with Bruker • High resolution brain white matter fiber structure • Fiber tract connections between major anatomical regions • Transport models for convection-enhanced CNS delivery • Natural product identification • ~1 mL of a “defensive ooze” from a leaf insect • We found 3 related pyrazines (smells like chocolate!) • Required the 1-mm HTS probe (right before it broke…) • Gene reporter for detection of cellular LacZ expression by MRI Pre Sgal Post Sgal -LacZ as of summer 2010, mid-point in current award period

  3. Development of NMR and MRI/S program at 30T and beyond • Microimaging program (1-2 mm3 FOV at micron resolution) • Measuring and matching of magnetic susceptibility • Development of contrast agents • NMR of biomolecular systems using microvolumes • Accelerated acquisition techniques • Managing and measuring anisotropic interactions • Transformational research • Signal detection in an extreme environment • Flow and diffusion over multiple length and timescales in deep structures • Bridging atomic and anatomical scales in biology • Systems biology and chemical communication • Renovation/expansion of AMRIS facility space • Development of program in multi-transmit/receive MRI Visionfor the AMRIS MRI/S Program as of summer 2010, mid-point in current award period

More Related