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Developing Backscattered Optical Radiation Model for Blood Microcirculation Measurements

Research at the MONIKI Institute aims to estimate blood microcirculation parameters using an analytical model. Laser Doppler Flowmetry and Pulse oximetry are utilized, leading to a novel diagnostic method. Mathematical simulation and clinical tests will further validate the model.

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Developing Backscattered Optical Radiation Model for Blood Microcirculation Measurements

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  1. Moscow Regional ResearchandClinical Institute “MONIKI” named after M.F. Vladimirsky Laboratory of Medical and Physics Research Development of backscattered optical radiation model for measuring parameters of the blood microcirculation system Research fellow: Lapitan D.G.

  2. The existing noninvasive methods for diagnostics of the blood microcirculation system Laser Doppler Flowmetry Tissue Reflectance Oximetry Pulse oximetry The aim of our study - estimation of the ratio between flux with the Doppler shifted signal and a total backscattered flux

  3. The classic task of interaction of optical radiation with matter

  4. The simple analytical model of the two-layered biological tissue Two light fluxes passing through our two-layered tissue model in forward and backward directions

  5. The spectra of backscattered light for different levels of the blood volume Vb The theoretically calculated spectra The experimentally measured spectra These results will be used to develop a new method for measuring the dynamic parameters of the blood microcirculation system (rhythms of micro hemodynamics)

  6. The intensity of the Doppler component in the total detected flux Dependences of the Doppler component Fd on the blood volume of the second layer for different values of b and 1: a) 1 = 100 cm-1, b) 1 = 500 cm-1, c) 1 = 1000 cm-1. - b = 100 cm-1, - b = 500 cm-1, - b = 1000 cm-1.

  7. The ratio of the Doppler component to the total backscattered flux Contribution of the Doppler component Fd in the total backscattered flux FBS as a function of the blood volume in the second layer for different values of b and 1: a) 1 = b = 100 cm-1, b) 1 = b = 500 cm-1, c) 1 = b = 1000 cm-1. A small useful signal in the Laser Doppler Flowmetry! Conclusion:the input optical radiation for real laser Doppler flowmeters can contains a lot of amplitude-modulated noise.

  8. Application of the model A new method for diagnostics of the blood microcirculation system which will allow measuring the blood perfusion and the dynamic parameters (rhythms of micro hemodynamics). Portable diagnostic device

  9. The structure of the research Development of the measurement model Mathematical simulation of the measurement model Development of hardware and software of the diagnostic device Conducting of clinical tests Introduction of this method in clinics

  10. Thank you for your attention! Laboratory of Medical and Physics Research “MONIKI” named after M.F. Vladimirskiy Tel/fax: +7 (495) 681-89-84 E-mail: lapitandenis@mail.ru www.medphyslab.ru

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