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Diafiltration : DF-101

Diafiltration : DF-101. Gordie Beamish Gordie Dipasquale Rob Fewchuk March 30, 2009. Process Overview Diafiltration Unit Filter Geometries Membranes Cleaning Methods. Diafiltration. Ultrafiltration using WFI Driving force is differential pressure

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Diafiltration : DF-101

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  1. Diafiltration:DF-101 Gordie Beamish Gordie Dipasquale Rob Fewchuk March 30, 2009

  2. Process Overview Diafiltration Unit Filter Geometries Membranes Cleaning Methods

  3. Diafiltration • Ultrafiltration using WFI • Driving force is differential pressure • Used to concentrate Trp-Proinsulin Process Overview

  4. Diafiltration Process Overview

  5. Process Overview Process Overview

  6. Diafiltration Unit • Complete System • Pumps, valves, piping, fittings, strainers, and control panel • Easy Installation • Made of AISI 316L Stainless steel • CIP procedures • 3 Vacuum/pressure pumps • Spiral wound filters Alfa Laval Membrane-UF Unit Diafiltration Unit

  7. How It Works Diafiltration Unit

  8. Types of Membranes Flat Sheet Hollow Fibre Tubular Spiral Wound Filter Geometries

  9. Spiral Wound Advantages Disadvantages • Difficulty in cleaning • Membrane deformation • High membrane packing density • Relatively low cost Filter Geometries

  10. Membrane Properties • Mechanical strength • Chemical resistance • Hydraulic permeability • Average porosity and pore size distribution • Sieving properties Membranes

  11. Types of Membranes Organic Polymers Inorganic Materials Membranes

  12. Types of Membranes Organic Polymers Inorganic Materials • γ-Alumina • α-Alumina • Borosilicate glass • Pyrolzed carbon • Zirconia/stainless steel • Zirconia carbon • Polysulfone (PS) • Polyethersulfone (PES) • Cellulose Acetate (CA) • Regenerated Cellulose • Plyamides (PA) • Polyvinylidedefluoride (PVDF) • Polyacrylonitrile (PAN) Membranes

  13. Polyethersulfone (PES) • Very Low Protein Binding • Fast Flow Rates • Hydrophilic • Wide Chemical Compatibility Range • Strength and Dimensional Stability • MWCO of 10,000 Membranes

  14. Cost of Polyethersulfone Diameter: 8” Length: 33” Area: 19.1m2 Cost: 2995$/membrane For our unit we need 5 membranes Price courtesy of KOCH Membrane Systems Membranes

  15. Cleaning/Disinfection • Two Step Process • Chlorine @ 200ppm at 50°C ½ h/day • Hot water: 80°C at 0.5 bar pressure drop/element, neutral pH for 5 min/day Cleaning Methods

  16. Questions?

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