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Featured Article :. Total and Cause-Specific Mortality by Elevated Transferrin Saturation and Hemochromatosis Genotype in Individuals With Diabetes: Two General Population Studies. Christina Ellervik, Thomas Mandrup-Poulsen, Anne Tybjærg-Hansen, and Børge G. Nordestgaard. Diabetes Care

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Featured Article :

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  1. Featured Article: Total and Cause-Specific Mortality by Elevated Transferrin Saturation and Hemochromatosis Genotype in Individuals With Diabetes: Two General Population Studies Christina Ellervik, Thomas Mandrup-Poulsen, Anne Tybjærg-Hansen, and Børge G. Nordestgaard Diabetes Care Volume 37: 444-452 February, 2014

  2. STUDY OBJECTIVE • Mortality is increased in: • Patients with hereditary hemochromatosis • Individuals in the general population with increased transferrin saturation (TS) • Patients with type 1 diabetes and increased TS in a highly specialized diabetes clinic • Targeted screening for TS is recommended in specialized diabetes clinics • Whether mortality is also increased in individuals from the general population with diabetes and increased TS is unknown Ellervik C. et al. Diabetes Care 2014;37:444-452

  3. STUDY DESIGN AND METHODS • Two Danish populations were studied • Mortality was studied in diabetes patients according to baseline levels of TS and hemochromatosis genotype (HFE) G → A substitution at nucleotide 845 in codon 282 (C282Y/C282Y) Ellervik C. et al. Diabetes Care 2014;37:444-452

  4. RESULTS • Cumulative survival rate was reduced in diabetes patients with TS ≥50% vs. <50%, with median survival ages of 66 and 79 years, respectively • Hazard ratio (HR) for TS ≥50% vs. <50% was 2.0 for total mortality overall, 2.6 for neoplasms, and 3.4 for endocrinological causes • Stepwise increased risk of total mortality was observed for stepwise increasing TS, with an HR for TS ≥70% vs. TS <20% of 4.8 Ellervik C. et al. Diabetes Care 2014;37:444-452

  5. RESULTS • HR for total mortality in individuals with diabetes for C282Y/C282Y versus wild-type/wild-type was 3.3 and for C282Y/C282Y and TS ≥50% versus wild-type/wild-type and TS <50% was 6.0 • 6% of premature deaths can be avoided by early screening for TS or HFE genotype Ellervik C. et al. Diabetes Care 2014;37:444-452

  6. Ellervik C. et al. Diabetes Care 2014;37:444-452

  7. Ellervik C. et al. Diabetes Care 2014;37:444-452

  8. Ellervik C. et al. Diabetes Care 2014;37:444-452

  9. Ellervik C. et al. Diabetes Care 2014;37:444-452

  10. CONCLUSIONS • Individuals with diabetes with increased TS or HFE genotype have a two- to sixfold increased risk of premature death Ellervik C. et al. Diabetes Care 2014;37:444-452

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