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Professor Hassan Nasrat

Sexual Differentiation Abnormal Sexual Differentiation of the Female Genital Tract (Normal and Abnormal). Professor Hassan Nasrat. Sexual Differentiation Abnormal Sexual Differentiation of the Female Genital Tract (Normal and Abnormal). Professor Hassan Nasrat.  Sexual determination:

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Professor Hassan Nasrat

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  1. Sexual Differentiation • Abnormal Sexual Differentiation of the Female Genital Tract (Normal and Abnormal) Professor Hassan Nasrat

  2. Sexual Differentiation • Abnormal Sexual Differentiation of the Female Genital Tract (Normal and Abnormal) Professor Hassan Nasrat

  3. Sexual determination: Sexual differentiation: : - GonadalDifferentiation: -Internal organ differentiation: -External organ differentiation: • Clinical Implications of Abnormal development and of DSD:

  4. Genetic Sex Determination (Genetic Sex)

  5. Genetic Sex Determination(Genetic Sex) The genetic (chromosomal) sex is determined at the time of conception (XX or XY).

  6. Testicular differentiation: The SRY gene acts as a switch or master gene for testis differentiation since it controls a whole number of further genes on the autosomes as well as on the X chromosome.

  7. Ovarian differentiation: ovarian differentiation used to be considered as the default process that spontaneously takes place in the absence of SRY chromosome. Now it is known that it involves an active genetic pathway (including R spondin 1 (Rspo1)/Wnt-4/beta-catenin signaling that is repressed by the presence of SRY).

  8. Gonadal Differentiation (Gonadal sex)

  9. The phase of indifferent gonads: (Up to 7 weeks)

  10. The indifferent gonads at 6 weeks show PGC surrounded by cells of the primitive sex cords, proliferation of the mesenchyme and the covering epithelium

  11. The phase of gonadal differentiation Testicular differentiation:begins during seventh week if the there is a Y chromosome that carries “SRY” gene. In the male the primitive sex cords form the testis and the rete testis cords. The latter communicate with tubules of the mesonephric system, thus linking the testis to the mesonephric duct. The mesonephric duct becomes the ductus deferens

  12. Ovarian differentiation: Begin at the 8th week (2 weeks after testicular The primitive sex cords degenerate. There is no communication between the gonadand the mesonephros

  13. Differentiation of the genital ducts (The internal genital organs)

  14. The Indifferent stage Up to the 7th week the internal genital organs consists of two canal systems: the mesonephric (Wolffian duct) and the Müllerian ducts (paramesonephric duct).

  15. Stage of ductal differentiation • Differentiation of male internal organs

  16. The atrophy of the paramesonephricduct • Müllerian inhibiting hormone (MIH). It is responsible for regression of the ipsilateral paramesonephric (Müllerian) ducts and is an example of local paracrine effect. The development anddifferentiation of the mesonephric duct • induced by testosterone, it involves development of the mesonephric ducts into the internal genitalia (vas deference, epididymis, and seminal vesicles). • Testosterone acts on the ipsilateral Wolffian duct.

  17. Differentiation of Female Internal Organs During the 7th week and in the absence of testes (MIH and testosterone) the canal system of the female sex organs differentiates.

  18. The mesonephric duct and its tubules atrophy and out of the paramesonephric duct (Müller) arises the future fallopian tube, the uterus and the upper part of the vagina Development of the fallopian tubes, uterus Sometimes the remnants of the Wolffian ducts form tubule like structures known as the epoöphorons, paroophorons and Gartner’s duct Development of the vagina derived from the Müllerian tubes while its lower 2/3 is derived from the urogenital sinus

  19. Differentiation of the External Genitalia

  20. The indifferent stage Both the urogenital sinus and the hind gut open into a common opening known as the Cloaca

  21. The cloaca is divided into the anorectal and urogenital regions as the urorectal septum contacts the cloacal membrane. The urogenital membrane and anal membrane then begin to break down. 50th days of gestation

  22. Abnormal Sexual Differentiation of the Female Genital Tract

  23. Abnormal sexual differentiation may occur as a result of defect in any one or more of the factors responsible for determination of sex i.e. chromosomal sex, gonadal sex, internal genital sex, and external genital sex. • The results may be identified immediately at birth as AmbiguousGenitalia (see lecture on sexual differentiation). • Alternatively, it may not be diagnosed until later at puberty as in the case of Intersex e.g. the XY female.

  24. Anomalies of the external genital organs Ambiguous Genitalia (Defect of the clitoris and labia)

  25. Anomalies of the Internal Genital Tract "Müllerian Anomalies"

  26. Normal development of the internal female genital tract depends on three consecutive embryologic processes: First:The differentiation of two paired mullerianducts. Second: lateral fusion of the lower segment of theMullerianducts in the midline to form the uterus, cervix and upper two third of the vagina. Finally:Resorptionof the central septum between the twoMullerianducts in order to form a single uterine cavity and cervix. The lower third of the vagina embryologically originates from the sinovaginal bulb. A normal patent vagina depends on complete fusion of the ascending sinovaginal bulb with the descending müllerian tubercle.

  27. Classification ofMulleriananomalies • Obstructive Mullerian anomalies. • Fusion Mullerian anomalies: • Agenesis / hypoplasia: • Miscellaneous anomalies (difficult to classify).

  28. Obstructive Müllerian anomalies Imperforate Hymen Clinical presentation and diagnosis Symptom Abdominal examination local inspection

  29. DD:

  30. The treatment of imperforate Hymen The treatment is by surgical drainage of the retained contents “the hematocolpos”.

  31. Cervical Atresia Isolated cervical genesis. Left isolated, Right vaginal and cervical atresia

  32. Vaginal Agenesis Transverse Vaginal Septum

  33. Defects of Mullerian Duct fusion Are relatively common (2-3%). usually presents with primarydysmenorrhea, fusion anomalies are often associated with gynecological as well as obstetrics complications such as infertility, recurrent pregnancy loss and poor obstetrics outcome in pregnancy.

  34. Complete failure of fusion of mullerian ducts didelphic uteri

  35. Uterus didelphys with vaginal septum. Rt: wit normal vaginal

  36. Partial failure of Mullerian tubes fusion Septet uterus: Left: partial (with minimum complications and not treatment required). Middle "bicornuateunicollis" septum reaches to the internal os. Right complete septum reaching external os "bicornuatebicollis"

  37. Anomalies due to unilateral defects of Mullerian duct development Left: Unicornuate uterus, Middle: horn communicating with the uterus, Right: horn not communicating with the uterus.

  38. Diethylstilbestrol Associated anomalies “DES”

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