noninvasive lung volume measurement

1. noninvasive lung volume measurement

2. what is emkaBELT? non-invasive tool to measure thoracic and abdominal volume based on the respiration inductance plethysmography (rip) monitors respiration monitors bronchoconstriction

3. what is respiratory inductance plethysmography (rip)? elastic and wire belts worn around the chest and abdomen. alternating current (AC) passed through belt generates a magnetic field. breathing changes the cross-sectional area of the animal’s body and shape of the belt’s magnetic field. this induces a change in resonance frequency of the circuit. the measure of this frequency provides a linear representation of cross-sectional area

4. what does it measure? 1/3 used without calibration (factory settings) provides exact values for: breathing frequency duration of inspiration and expiration duration ratios asynchrony between thoracic and abdominal movements (phase shift) apnea, emesis, cough indications of absolute values and assessment of relative changes for: tidal volume and minute ventilation maximum and minimum flow

5. what does it measure? 2/3 used with calibration precise, subject specific calibration is possible with a mask requires 2 min procedure prior to recording uses extra data channel linked to fleisch tube & mask provides exact values for: tidal volume and minute ventilation maximum and minimum flows relative contribution of thorax and abdomen

6. what does it measure? 3/3 bronchoconstriction assessed with phase asynchrony in abdominal and thoracic signals and the calculation of phase angle from: thoracic vs. abdominal loops (dogs) abdominal vs. thoracic loops (primates)

7. the emkaBELT system elements 2 extension belts (with connectors) 1 emkaPACK transmitter equipped with 1 integrated emkaBELT module 1 receiver

8. fitting respiration belts to the animal

9. calibration of respiration belts

10. ecg & respiration breath by breath analysis of respiration ecg (dog) lung volume (dog)

11. ecg & respiration breath by breath analysis of respiration flows (dog)

12. correlation between belt and flow-derived volume thoracic signal volume from mask abdominal signal flow from mask signal from belt volume from mask

13. in the absence of drugs there is good synchrony of thoracic & abdominal signals courtesy of CIT baseline period: near perfect synchrony

14. carbachol (a brochoconstrictor) induces asynchrony of thoracic & abdominal signals courtesy of CIT 30 mn after administration: near total asynchrony

15. control data before adminstration of theophylline courtesy of Pfizer, Groton control dose methylcellulose

16. effects of theophylline (bronchodilator / stimulant -3mg/kg po) on signal shape courtesy of Pfizer,Groton 10 minutes post-dose

17. effects of theophylline on respiratory rate courtesy of Pfizer, Groton 4 dog group results for theophylline (3mg/kg po) baseline dose

18. effects of nebulized methylcholine (2mg/mL) on phase angle courtesy of Pfizer, Groton Breath waveforms are in near perfect phase opposition.

19. effects of nebulized methylcholine (2mg/mL) on phase angle courtesy of Pfizer, Groton 4 animal group results baseline control dose

20. recovery from ascaris suum-cynomologus macaques courtesy of Schering-Plough abdominal & thoracic signals during anesthesia (left) and during challenge (right)

21. recovery from ascaris suum-cynomologus macaques courtesy of Schering-Plough asynchrony changes as displayed by thoracic/abdominal volume loops

22. why use emkaBELT? signal quality is excellent belt length is easily adjustable to animal size calibration from mask is valid, reliable and easy positive controls repeatedly produce expected effects asynchrony (phase shift) assessment is an efficient and reliable indicator of bronchoconstriction apnea is detected using shape-recognition algorithm

23. why use emkaBELT? inclusion of safety pharmacology endpoints into general toxicology studies “Safety pharmacology studies measure functional indices of potential toxicity. These functional indices may be investigated in separate studies or incorporated in the design of toxicity studies.” (ICH S6) “An assessment of vital organ function, including cardiovascular, respiratory and central nervous systems, should be available before the initiation of clinical studies; such parameters could be included in general toxicology studies.” (ICH S9)

24. emka TECHNOLOGIES’ telemetry is open it provides analog outputs at no extra cost so you can use the software of your choice!

25. website visit our websites for complete product descriptions, case studies, a knowledge base, & frequently asked questions: www.emka.fr & telemetry.emka.fr

26. contact us! please contact us to see how we can help you meet your telemetry research goals! whatever the scale and complexity of your project, please contact us for a professional, competitively priced solutions adapted to your needs  emka TECHNOLOGIES S.A. 59, bd. général Martial Valin - 75015 Paris - FRANCE phone: +33 (0)1 40 60 76 00 fax: +33 (0)1 40 60 65 66 sales and support office for North America: emka TECHNOLOGIES Inc. 307 Annandale Road, suite 203 Falls Church, VA 22042 - USA phone: +1 (703) 237-9001 fax: +1 (703) 237-9006 for all inquiries contact : sales@emka.fr distributor for China: Beijing GuangYuanDa Science and Technology Co. Ltd. Suite 305 Hongchen Business Center,No 20 ZhongFangLi, Chaoyang District, Beijing 100020 phone: +86-10-65019453 fax: +86-10-65019453 contact: information@bjgyd.com distributor for Japan: Physio-Tech Co., Ltd 6-3, Iwamoto Cho 1-Chome Chiyoda-Ku, Tokyo 101-0032 +81 3 3864 2781 +81 3 3864 2787 contact: emka@physio-tech.co.jp Physio-Tech website: www.physio-tech.co.jp