Structural Genomics, ISGO, and Structural Genomics Task Forces

1. Structural Genomics, ISGO, and Structural Genomics Task Forces Open ISGO Structural Genomics Task Force Meeting ISGO International Structural Genomics Conference Berlin, 10 October 2002 Udo Heinemann (MDC, Berlin)

2. Structural Genomics A large-scale project to determine the three-dimensional shapes of all proteins and other important biomolecules encoded by the genomes of key organisms Definition phrased at the April 2001 Second International Structural Genomics Meeting, Airlie House, VA, USA

3. Structural Genomics • The Structural Genomics Project aims at determination of the 3D structure of all proteins. • This aim can be achieved in four steps: • Organize known protein sequences into families. • Select family representatives as targets. • Solve the 3D structure of targets by X-ray crystallography or NMR spectroscopy. • Build models for other proteins by homology to solved 3D structures. • http://www.structuralgenomics.org/main.html

4. A Brief History of Structural Genomics • 1995 SG project proposed in Japan • 1997 Apr. SG pilot project starts at RIKEN Inst. • 1997 SG studies initiated through DOE, NIGMS in US • 1998/99 Initial SG projects start in Canada, Germany, US • 1999 June Call for SG pilot projects issued by NIGMS/NIH • 2000 Jan. OECD Committee for Scientific and Technological Policy (CSTP) proposes to initiate SG studies • 2000 Apr. 1st International SG Meeting, Hinxton, UK • 2000 June OECD/Global Science Forum (GSF) and SG Workshop, Florence, Italy • 2000 Sep. SG: From Gene to Structure to Function, Cambridge, UK 2000 Sep. NIGMS Protein Structure Initiative starts in US with 7 Centers 2000 Nov. International Conference on SG (ICSG 2000), Yokohama, Japan / International SG Task Force Meeting / OECD/GSF Meeting 2001 Jan. OECD/CSTP/GSF, Paris, France – Further Study on SG 2001 Apr. 2nd International SG Meeting, Airlie House, US – Start of ISGO 2001 Sep. NIGMS Protein Structure Initiative adds 2 new centers 2002 Mar. European Commission announces funding of Structural Proteomics in Europe (SPINE) 2002 Apr. National project on Protein Structural and Functional Analyses starts in Japan 2002 Oct. ISGO International Conference on SG (ICSG 2002), Berlin, Germany

5. Canada Projects Europe France Germany Japan Taken from www.isgo.org Korea Switzerland UK USA

6. Structural Genomics: A large-scale project to determine the three-dimensional shapes of all proteins and other important biomolecules encoded by the genomes of key organisms SGis genome-driven, aims at completeness SGneeds high throughput, automation SGneeds international coordination to foster cooperation and avoid waste of resources Structural Genomics

7. International Coordination • International agreements • The projects make their structure analysis targets public (Target Tracking) • The projects grant mutual technical help • Protein structures from structural genomics projects must meet stringent quality criteria • The structures are published in a timely manner • Deriving utility from protein structures is not excluded www.proteinstrukturfabrik.de

8. The International Structural Genomics Organisation (ISGO) • Initiated at Airlie House Meeting (2001) • Activities • International coordination (task forces) • Workshops, meetings • Conferences • Appointed officers • Udo Heinemann (Germany / Europe) • Tom Terwilliger (USA / North America) • Shigeyuki Yokoyama (Japan / Asia)

9. Structural Genomics Taskforces Informatics (J. Moult, U. Maryland, USA) Numerical Criteria for Evaluating and Assuring Structure Quality (R. Read, U. Cambridge, UK) Tracking and Registra-tion of Targets (S. Bryant, NIH, Bethesda, USA) Deposition, Archiving, and Curation of the Primary Information (H. Berman, Rutgers U., USA) Mechanisms for Publication and Recording of Methods (G. Dodson, U. York, UK) Intellectual Property (B. Skene, Wellcome Trust, UK, and J. Norvell, NIGMS, USA)