Tips for Getting the Best Results While Having Prostate Cancer Surgery

1. Tips for Getting the Best Results While Having Prostate Cancer Surgery You've probably had a lot of discussions with friends and family and certainly your doctors about this. It's tough because there are competing goals and values you have to consider when deciding about surgery. Some of the more important ones that many men consider are returning to their sexual health baseline after treatment. This is probably the most variable thing for some men. This is very important for some men, not as important, and men's sexual health baseline in their 50s and 60s vary quite a bit. Most men find retaining control of their urinary function to be very important. As a side note, prostate cancer surgery can also help men who have a blockage or straining to urinate by removing that tissue. A key goal for almost all guys is being cancer-free. Of course, you're having treatment to get rid of this cancer, and you don't want it to come back. And finally, men want to get back to their normal life as soon as possible, work, recreation, family, and so forth. So your surgeon will certainly help you in maximizing these outcomes, but there are some things that you can do in terms of engaging, asking questions, and doing your homework, in terms of getting the best outcomes. But first, why is this so complicated? Why are these things so interrelated? As a brief review, it's because of the anatomy. So this is the prostate gland right here. It's part of the male reproductive system, and its job is to produce the fluid in the ejaculate that helps the sperm to live and initiate a pregnancy. So, for many men, when they've been diagnosed with prostate cancer in their 50s or 60s or 70s, that function is not so important anymore, so it isn't doing a whole lot for you. However, removing it does risk important things that you do care about, so, for example, these yellow structures are the nerves that come down from the brain and end up innervating the penis, so they don't cause the sensation of the penis, but they trigger the arteries in the penis to open up and possibly fill with blood during sex, giving you an erection. So you can see here, these nerves live right on the surface of the prostate gland, and when you take that gland out, you've got to sweep those nerves off very carefully-- that's called nerve-sparing--to preserve normal sexual function.

2. Sometimes the cancer is right at the surface there, and the nerve can be involved, and if you save that nerve, you could leave cancer behind. The second issue is that this thin tube here going through the penis, called the urethra, allows the urine from the bladder to come out the prostate, sits right in the middle there, and the urethra goes through it like a hole in the doughnut. So when you remove the prostate, you've gotta sew the bladder to the remainder of the urethra, It comes down just fine but takes some time for things to heal up down there, and you can leak urine for a while after surgery as a result. So, how about sexual health? How can you maximize your outcomes? There are some things you can't control, like your baseline sexual health function-- some men are using Viagra or having weak erections on Viagra--and that predicts how well you'll do after surgery. The best outcomes are for men who have excellent sexual health, go but take actions off of Viagra, other medical conditions can affect things, blood pressure can affect the health of the penile arteries. You can maximize your optimize your diabetes control, optimize your blood pressure control be sexual health to try to improve very important things, and your age on viagra its how well you'll do in terms of sexual health after surgery, so older men tend to have a lower chance of getting back to their baseline than younger men, say, men under 65. But there are some things that you can take action on, perhaps help. One of these is learning whether nerve-sparing is possible, and the other is the post treatment rehabilitation approach to sexual health. The final thing is the surgeon's experience. So, is nerve-sparing possible? So, there are many surgeons. They determine this based on the physical exam of the prostate gland--that is, looking for nodularity there that implies that the cancer is involving the nerves. They will use calculators that

3. say what's a chance, there is on the person's PSAnerve-sparingveness score, that the tumor is at the lining of the prostate or not. And also, during surgery, see if the neurosurgeon experience easily or nerve-sparingidence that it's kind of sticky, as a way to judge whether the cancer is involved. A newer way to assess the risk of, you know, whether nerve-sparing can be done is using preoperative MRI of the nerve state gland. There been several studies on this, and one study looking at all the existing studies, called a meta-analysis, concluded their prostate MRI changed the plan, in terms of nerve-sparing, in about 1/3 of the men. And in those cases, essentially perhaps half of them, the nerve was spared when it was going to be taken, according to initial surgeon experience that's nerve-sparing better chance to get sexual health back, and in half the cases, the nerve was taken because the MRI indicated cancer had extended into the nerve where the surgeon was not thinking it had, which results in better cancenerve-sparing, some caveats with that. MRIs are not uniform, so the quality of MRI does vary by where you get it and by the experience of the radiologist who reads the MRI for the surgeon. So if you inquire about getting a preoperative MRI, you should make sure that the surgeon is sending it somewhere where they do a lot of them and the radiologists are familiar with them because there's about a 50/50 chance that radiologists would disagree about prostate MRI findings, so you want to go somewhere with a lot of experience. Regardless of that, ones that I did find that in one in four patients who had nerves taken, that they could have been spared, had the MRI been used to guide decision-making. So, it can be helpful, and one other caveat is that if you've had biopsy already, and it was not done with the help of MRI guidance--and you can get an MRI right after your biopsy--you have to wait for 2-4 weeks for the bruising in the prostate to go down so that there are better pictures obtained for the radiologist. Another way you can take action, perhaps, help yourself, is asking about penile rehabilitation, it's called. This is a formal program to try to maximize the chances that the nerves will function after surgery. Even if the nerves are spared, when they're pushed off the prostate, they're stretched and the word for that is neuropraxia, and it takes a while for the nerves to recover from that stretching injury. They heal at a micron per day rate, so you have up to 12 months to get your full sexual health back, and during that time, you can do things to improve your chances of getting sexual activity back in your life. There are many protocols in this regard. Most of them start with a low dose of what's called a phosphodiesterase-5 inhibitor, which is like a Viagra or Cialis, it doesn't matter which one--it isn't the dosage that we would use to have you get an erection. It's a low dose to try to allow for better recovery of the nerve and also for better penile health, in terms of reducing scarring in the penis. You might know that when a nerve is damaged at the muscle, that its supplies can become withered away, and similarly if a nerve is stretched, the penis can have changes in its architecture and make the ability get erection worse, even if the nerve heals back completely, so we think these drugs help the penis stay healthy and avoid scarring inside the penis. They also will use vacuum devices, basically pump devices that mechanically let you have an erection to prevent the

4. scarring process, and some men have to use injections of the small diabetic-size needle of a liquid type Viagra that gives you a really good erection. One meta-analysis we're looking at, all the studies in this area found that these types of protocols did improve the proportion of men who improved, in terms of sexual health, after surgery by a factor of two, but what's less clear is whether those men have a better spontaneous erection rate when they stop these interventions--so the protocols do improve sexual health, it's important to discuss with your surgeon what their protocol might be, or if they don't know, to read about that and go on one, but yeah, we're not clear about whether these things are going to give men the ability to be better active off of Viagra or Cialis. Another topic in sexual health is surgeon volume. So, it makes sense that the more of something that you do, the better you are at it, and nerve-sparing is a delicate procedure that tends to improve, in terms of success, with volume. That is not a hard and fast rule- -some studies show that you know, one study showed that in the top high-volume surgeons, about 8% of them were responsible in the top 1% of the complication rate, so surgeon volume is, directionally, the thing to look for--it isn't a perfect guide to finding a good surgeon, but nerve-sparingly a good bit of information to have. It's hard to pin down the exact relationship between sugar hardline and sexual some studies show these days are done on using your insurance claim to say who was on pills or who was having surgery for problems after prostate cancer surgery, but a lot of guys don't take pills and don't have surgeries after this for these purposes, so you miss their experience. One major medical center did a careful study where they asked men after surgery every 3 months how they were doing in terms of sexual health, and they did find that volume--okay, so I'm greater than a hundred cases--was associated with better sexual health outcomes, and their patients had also better urine health outcomes, less incontinence, and that both those outcomes tended to vary together without a sacrifice of cancer control, which is pretty convincing, but just to emphasize the topic here, this is that data from that study, and you can see here the average was 30% of probability of sexual health recovery at 12 months. This is all comers, so, guys that started with the bad disease, that had their nerves have taken, that are older, and younger guys, that had the nerve spared, so it's kind of an average of everybody. Anyways, here is an individual surgeon. There's a lot of variation in terms of how they did, but what they found was that when they did a subset analysis of just the surgeons who had over 500-lifetime cases, there was still this kind of variability, so it's not a perfect guide, volume, but it's something to ask about and think about in terms of urinary control. The surgery takes, as I mentioned, the prostate out, and the urinary sphincter muscle, which helps you control your urine when you cough or sneeze and have you not have an accident, needs to be sewn back to the bladder, and that muscle also takes time to heal and get strong again, and the typical way that we ask patients to take some action and improve their health is by doing Kegel exercises after surgery. Kegel exercises are exercises where you contract the muscles that you would use to hold your urine. So, if you could imagine you're standing at a urinal and you've got to stop urinating, suddenly a fire alarm goes off or whatever, you would contract muscles deep

5. in your pelvis, kind of near the rectal muscles, leave your abdominal muscles soft, and you hold that contraction for 10 seconds and let it go. There are a lot of different protocols on how often you have to do this after surgery, to contract these muscles. They vary mainly on the fact that it's hard to remember to do this, and what's the easiest way to get a guy to remember to do this? During the day, I tell patients to hold it for 10 seconds and do it 10times an hour while you're awake. The more you do, the better. You should also do a Kegel after surgery when you stand up quickly, sneeze, or gonna laugh, that helps keep you dry, and definitely, our data do suggest that people that follow-up protocol of pelvic rehabilitation in this area are more likely to recover urinary control. There is weaker evidence--and say that you can, if you do this before surgery, some patients are encouraged to start doing Kegels ahead of time--it's not clear that helps, and for some patients, they're referred to what's called biofeedback after surgery, where electrodes are placed on the muscles, and they can see the contractions when they contract--it's not clear that is always effective, but if patients have a hard time localizing the muscles or doing the exercises, we will often send to a physical therapist for further training. They specifically understand what to do, and physical therapists are often very good at teaching this, so depends on the person and motivation, but this is a great way to help you get back your urinary control. And again, this does vary by surgeon volume. This is data from that study. You can see that of the surgeons, there's a wide variety in terms of how many men are controlling their urine at 12 months. Cancer control is a key outcome after surgery, and surgery experience does matter here. One of the best studies is about 8,000 patients and 72 surgeons, and that's how they found that results plateaued after a surgeon's done about 250 cases. So the patients that had the lowest volume had about an 18% cancer recurrence rate--that means that their PSA became measurable again after surgery--versus 11% where the guys that had the most experience, or the surgeons have the most experience, after about 250 cases, and this is confirmed in several meta-analyses, and this brings us to the question of, how do you pick a surgeon? This is a thing that you can do to maximize your chances, and, you know, there are a few different domains to consider. First, of course, is the connection you have with the surgeon. Are you on the same page in terms of your goals? Is he or she listening to you? Critical, just gotta check. I think also volume is important, but with a caveat, that volume isn't everything. I think you can also look at whether your surgeon offers different programs for rehabilitation, considers that important, and makes it part of their practice, as an indicator of how important they see these things, and finally, the support services around the surgeon. Do they have a physical therapist at work? Do they have a good radiologist to work with? Is there maybe clinical trials or a program for more complicated patients? Those are things to consider. Another thing that's interesting to note is that we are in an age now where virtual reality is helping us operate better. This is an example of how we may be able to improve our outcomes. We have a new study where we're using the patient's preoperative MRI and plugging that data into our virtual reality model that we see during surgery. So on this slide, it's an example of what we would see when we're using the surgical robot alongside the live version of the prostate, and the yellow, you see the

6. nerves that are specific for this actual patient, and the red is where his tumors are, so with this, we can get a sense of what are we looking at, and how does it relate to the patient's MRI, and hopefully do a better job of sparing the nerves and also controlling cancer. In a prior study, we did this in patients who had kidney cancers, and we noticed that there was reduced operative time, reduced blood loss, fewer complications, and better cancer control, as well as shorter length of stay. Finally, We want to talk about getting home and getting back to normal. So, a key parameter here is intraoperative blood loss. Some surgeons offer this surgery as open surgery and some as robotic surgery. We'd say robotic surgery is becoming quite dominant now, and with robotic surgery, one of the biggest differences is there is less blood loss, mainly because there is CO2 gas that's put into the abdomen during surgery to sort of blow it up, we can see--and that puts pressure on all the veins that ooze from the prostate when we're removing it, and that controls blood loss a lot better. When you have less blood loss, you have a faster recovery, you feel better after surgery and go home quicker. And finally, a really important point is the use of opioids after surgery. You may have heard about the opioid epidemic in this country, and it caused many surgeons to look at their prescribing practices and see what's needed. Of course, our primary goal is to keep people comfortable, but we don't want to have any side effects, so one study was done recently found that 3/4 of the patients who had a robotic prostatectomy, the pain meds were never used, and so what that results is in a bottle sitting in your medicine cabinet. That's a key reason that other people can find it, take it, and it can be a problem. Another study found that in 84% of patients after the surgery, fewer than 15 oxycodone, say, are required. That's about less than four days of pain medication. Opioids can be constipating, they can be addicting, and they can cause lethargy, and constipation can be a big problem after this kind of surgery, so we often will suggest, if your pain isn't horrible, that you try a narcotic pain medication, and then 6hours later try a Tylenol or Motrin, then go back to the narcotic and see if you can wean yourself off of it as soon as possible. And we try to prescribe fewer pills, that are in line with what people use, to prevent the risk of someone else getting ahold of unused tablets. All right, so one question is, "To find a surgeon with caseloads for 250+, is this data that doctors must share if I ask?" The answer is no. Most surgeons are aware of how many of these cases they've done, and these days We'd say that after the advent of robotic surgery, the proportion of urological surgeons doing the surgery is to drop, so the cases are happening in a smaller number of people's hands, and those people tend to know how many cases they've done. "How much you live with prostate cancer?" So that's like a question about survival. So, the good news is that prostate cancer is very slow-growing, and one large study from the UK found that in all comers, that 10-year death rate was around 1%, and this was even true in patients who had what's called active surveillance. Of course, many of those people ended up on hormone therapy, but the chances of dying anytime soon are very low. The long-term horizon, though, of course, 15 or 20 years. This can be a cause of mortality, and so for men who have a

7. longer life expectancy, treatment is indicated. "How to decide while using chemotherapy or a surgical approach?" Chemotherapy is used Only when the prostate cancer spread at the external part of the prostate gland. It goes all over your body, so that's called metastatic prostate cancer. Surgery is used in patients where the cancer is just in the prostate, so we feel we can cure you by removing it. If you've got cancer elsewhere in your body, typically, taking out the prostate gland will not affect your overall survival. There are some studies on this topic, but they are pretty early days. "What is the origin point of disease, and how to prevent it?" So, it is genetic reasons behind it. Some of these factors are things you really can't control. Your body accumulates changes in the genes as you get older because of various exposures, and we don't know how to exactly prevent at that level. In terms of dietary changes, heart-healthy things tend to be prostate cancer healthy, so keeping a good body weight, a Mediterranean diet, keeping yourself physically active, and, you know, in large, population-based studies, those things are associated with less prostate cancer and better outcomes. There was one study about the Japanese diet, which is heavy in vegetables, and they followed patients as their families emigrated from Japan to Hawaii to the US, and the adoption of a Western diet seemed to increase the risk of prostate cancer in patients who had very similar genetic makeups. And "How is prostate cancer typically diagnosed? Should I contact a urologist or an oncologist?" Well, prostate cancer is treated by a prostate biopsy, so what happens is we've got a blood test first, usually, you got a test for--it's called a PSA, or prostate-specific antigen, if that's abnormal or if your rectal exam result shows unnatural, your doctor will refer you to a urologist for a biopsy, and that's done in the clinic, and they will let you know what they find. UrologyCapeTown provides prostate treatment in cape town, Our urologist Drs Eppel and Smit combine their extensive knowledge, expertise, and experience using different treatment modalities, to provide an individual approach that is objective, to find the least invasive but most effective treatment for you. For more info call us at +27 (0) 21 424 1626 or email at leilah@urologycapetown.co.za, or https://www.urologycapetown.co.za Visit our website at: