The Infectious Diseases Institute Kampala, Uganda

1. The Infectious Diseases InstituteKampala, Uganda InfoPoverty World Conference United Nations Robert L. Mallett Senior Vice President Corporate Affairs Pfizer Inc

2. What We Do Compound Success Rates by Stage Years 0 Discovery (2–10 Years) 2 Preclinical Testing Laboratory and Animal Testing 5,000–10,000Screened 4 6 250Enter Preclinical Testing Phase I 20–80 Healthy Volunteers Used to Determine Safety and Dosage Phase II100–300 Patient Volunteers Used to Look for Efficacy and Side Effects 8 10 Phase III1,000–5,000 Patient Volunteers Used to Monitor Adverse Reactions to Long-term Use 5Enter Clinical Testing 12 FDA Review Approval 14 Additional Post-marketing Testing 16 1Approved by the FDA Source: PhRMA, based on data from Center for the Study of Drug Development, Tufts University, 1995

3. What We Believe Guiding Principles • Effective Social Investment • We Focus on Where We Add the Greatest Value • Long-Term Commitment to Health Problems • Focus on Achievable, Measurable Health Outcomes • Leverage the Full Resources of the Company • Fostering Innovative Approaches to Public Health Challenges • We Have More to Offer Than Money • Medicines, Organizational Influence, Leadership, and Our People • We Cannot Do It Alone • We Work in Partnership

4. How We Help Global Health: Systemic Improvements in Building Capacity Access to Medicines • Infrastructure Development • Health Provider Training • Company Expertise • Patient Education • Pfizer People

5. Absence of Primary Health Care Infrastructure Lack of Trained Health Care Professionals Transient, Mobile Patient Populations Lack of Equipment and Medical Facilities Vertical Programs Responsive, Engaging Government Existing Medical School with Significant HIV/AIDS Expertise Stable Environment Resources and International Donors Health Care in Uganda: Challenges and Opportunities Opportunities Challenges

6. Infectious Diseases Institute, Kampala, Uganda Goal: To Build and Sustain Regional Clinic, Laboratory and Medical Training Center for the Diagnosis, Treatment and Prevention of HIV/AIDS

7. Model Partnership • Makerere University in Kampala • One of the Leading Medical Schools on the Continent • San Francisco AIDS Foundation/Pangaea • Program Administration and Project Manager for Construction • Infectious Diseases Society of America (IDSA) • Developed Intensive Month-Long HIV/AIDS Training Curriculum and Provides Trainers • The AIDS Support Organization (TASO) • Largest Indigenous Organization in Africa Providing Patient Counseling and Support • Pfizer • Financial Support and Technical Assistance (e.g. Pfizer Engineers and IT Support; Medicines; Pfizer Global Health Fellows)

8. IDI Technology Needs Infrastructure/Wiring Integration of Clinical Laboratory System Identification and Implementation of an Electronic Record Keeping System Installation of a Research Database to Administer Data Collection for Clinical Trials Creation of a Clinical Training Program for New Physicians Donors ($1.8M in IT support ) Pfizer Microsoft Cisco SAS Oracle Hewlett Packard Elsevier Science Skyscape PALM Inc Matching Needs to Resources

9. Impact of Infectious Diseases Institute • Training • 200 Physicians Trained Each Year • Treatment • 3,000+ Patients Receive Regular Care • Operational Research • New Studies on Adherence • Prevention and Outreach • Counseling for Patients • AIDS Center Provides Information for Physicians

10. Critical But Unforeseen Benefits • Workplace Safety Program • Transferring World Class Health & Safety Standards • Makerere School of Architecture • Students Benefiting From Project Engineering and Architecture • Local Procurement of Resources • Support Kampala Economy • Creating Entrepreneurial Opportunities • Local Contracting Company Won Bid to Construct New British High Commission • Sharing Best Practices • Pfizer Promoting Lessons Learned