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GeneGroupAnalysis 1.0.0- BetaCS

GeneGroupAnalysis 1.0.0- BetaCS. Alejandro Quiroz- Zárate John Quackenbush lab http:// compbio.dfci.harvard.edu / compbio. The “usual” analysis. The Key Idea. This methodology was developed with Dr. John Quackenbush. GeneGroupAnalysis 1.2.0. Go to. Example (real data set)

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GeneGroupAnalysis 1.0.0- BetaCS

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  1. GeneGroupAnalysis1.0.0-BetaCS Alejandro Quiroz-Zárate John Quackenbush lab http://compbio.dfci.harvard.edu/compbio

  2. The “usual” analysis

  3. The Key Idea • This methodology was developed with Dr. John Quackenbush

  4. GeneGroupAnalysis 1.2.0

  5. Go to • Example (real data set) • Gene expression from tumor samples • 209 ER+ and 135 E- • GEO reference accession numbers:GSE2034,GSE5327 • Affymetrix U133A • Conceive the data set with aCross-Sectional Design • Question of interest: • What are the biological mechanisms that drive the differences in Estrogen Receptor status?

  6. Estrogen Targets Tissues

  7. Estrogen and Cancer

  8. Estrogen Receptors Trigger Gene Activation

  9. Estrogen Receptor-Negative Breast Cancer

  10. Analysis

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