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Hydrogen sulfide and meningitis Supplemental Digital Content 1. Serial MR images showing the changes in the apparent diffusion coefficient (ADC) over time, represented in color, superimposed on the fluid attenuated inversion recovery (FLAIR) MRI images. The changes in ADC are shown as decreasing (more blue, more cytotoxic edema) or increasing (more red) according to the color scales shown at the right of the figure, and computed with respect to the admission study. A ventriculoperitoneal shunt was placed in the right hemisphere, causing artifacts; only changes in the left hemisphere are shown. However these are representative of globalchanges, described in more detail in the text. Contiguous spread seen in bilateral cortices and deep gray nuclei is inconsistent with a vascular distribution.