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Packaging for Cream

Packaging for Cream. Kausar Ahmad Kulliyyah of Pharmacy. http://staff.iium.edu.my/akausar. Contents. Introduction. Packaging Suitability. Primary Packaging . Unit dose packaging. plastic tubes caps that snap off, twist off and pierce to open. liquid, ointment. 1 to 5 ml sizes

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Packaging for Cream

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  1. Packaging for Cream Kausar Ahmad Kulliyyah of Pharmacy http://staff.iium.edu.my/akausar PHM4153 Dosage Design 2 2011/12

  2. Contents PHM4153 Dosage Design 2 2011/12

  3. Introduction PHM4153 Dosage Design 2 2011/12

  4. Packaging Suitability PHM4153 Dosage Design 2 2011/12

  5. Primary Packaging PHM4153 Dosage Design 2 2011/12

  6. Unit dose packaging • plastic tubes • caps that snap off, twist off and pierce to open. • liquid, ointment. • 1 to 5 ml sizes • can have reclosable or non-reclosable caps. PHM4153 Dosage Design 2 2011/12

  7. Containers for creams PHM4153 Dosage Design 2 2011/12

  8. Packaging Materials PHM4153 Dosage Design 2 2011/12

  9. Packaging Materials Inspection PHM4153 Dosage Design 2 2011/12

  10. Metals PHM4153 Dosage Design 2 2011/12

  11. A study on internal surfaces of Al tube PHM4153 Dosage Design 2 2011/12

  12. Problems with Al tube PHM4153 Dosage Design 2 2011/12

  13. Polymers - plastics PHM4153 Dosage Design 2 2011/12

  14. Additives in Polymers • Add other substances to improve stability, processing behaviour, or in-use performance. • E.g. PVC • need stabilizers, softeners? • Vulnerable to oxidation • Add antioxidants • These chemicals should not interact with product PHM4153 Dosage Design 2 2011/12

  15. Ideal Closures Seal the container to prevent loss of product and ingress of gases or other substances Withstand sterilization process Prevent contamination by micro-organism Non-reactive Easily remove and replace the closure and reseal (best reseal with glass fusion) Material? PHM4153 Dosage Design 2 2011/12

  16. Basic types of closure PHM4153 Dosage Design 2 2011/12

  17. Filling of Cream PHM4153 Dosage Design 2 2011/12

  18. Packaging equipment - liquid filler Capacities range from 15ml up to 1 gallon with neck finishes of 28mm and larger PHM4153 Dosage Design 2 2011/12

  19. SECONDARY PACKAGING PHM4153 Dosage Design 2 2011/12

  20. Packaging and Labeling requirements PHM4153 Dosage Design 2 2011/12

  21. AIR CONTROL SYSTEM PHM4153 Dosage Design 2 2011/12

  22. COMPRESSED AIR SYSTEM • oil free • hydrocarbon free • dessicant system (-40°c dew point) • to prevent air condensation inside packaging that can affect the quality of products when temperatures vary PHM4153 Dosage Design 2 2011/12

  23. ELECTRONIC INSPECTION SYSTEM (WITH CAMERA) PHM4153 Dosage Design 2 2011/12

  24. References http://www.pharmaceuticalonline.com/ http://www.ropack.com/cadre.html http://www.botlab.com/production.asp Pizzolitto, E. L., Pizzolitto, A. C. & Pozetti, G. L. (2001). Braz. J. Microbio. 32:4 PHM4153 Dosage Design 2 2011/12

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