Bioinformatics Core

1. Bioinformatics Core Lang Li Center for Computational Biology and Bioinformatics Division of Biostatistics Department of Medicine

2. Bioinformatics Core Structure Bioinformatics core (directed by Lang Li) CCBB faculty Analyst 1 Faculty 1 Lab 1 Analyst 2 Faculty 2 Lab 2 … … … Bioinformatics Leader Analyst N Faculty N Lab N … Microarray core(s) Proteomics core Sequencing core

3. Research area covered by CCBB and Bioinformatics core • Genetics • Population genetics • Pharmacogenetics • Functional Genomics • Epigenetic regulation • Transcriptional regulation • Gene expression • Post-transcriptional regulation • Proteomics/Metabolomics • Mass spectrometry data analysis • Protein structure prediction • Drug screening • Pharmacometrics • Pharmacokinetics • Pharmacodynamics • Disease models Lang Li Tatiana Foroud Jeesun Jung Shen Li DNA transcription • Yunlong Liu • Lang Li • Changyu Shen mRNA translation • Changyu Shen Jake Chen • Yaoqi Zhou • Keith Dunker Vladimir Uversky Protein • Samy Meroueh Drug • Lang Li • Robert Bies

4. http://compbio.iupui.edu/

5. http://compbio.iupui.edu/

7. Sequence Analysis pipeline Sequencing Core Bioinformatics Core

8. High throughput data management • caArray system is established at Bioinformatics core • myTrack system for next generation sequencing data Manage, compare, share and publish high throughput data produced using next generation sequencing technology

9. Our team! • Genetics/Genomics • Lang Li, Tatiana Foroud, Jeesun Jung, Shen Li • Functional Genomics • Yunlong Liu, Lang Li, Changyu Shen • Proteomics/Metabolomics • Changyu Shen and Jake Chen (high throughput technology) • Yaoqi Zhou, Keith Dunker, Vladimir Uversky (protein structure/disorder) • Drug screening • Samy Meroueh • Pharmacometrics • Lang Li, Robert Bies

10. Contact Info • Lang Li, lali@iupui.edu • http://compbio.iupui.edu/core