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Research areas

Dr. Andrew Clark Associate Professor in Synthetic Chemistry. Research areas. Natural product isolation and total synthesis. Chemistry and biology of free radicals. Development of synthetic methodology using copper, iron and ruthenium. Functional Genomics / Chemical Genetics / Interactomics.

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Research areas

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  1. Dr. Andrew Clark Associate Professor in Synthetic Chemistry Research areas Natural product isolation and total synthesis. Chemistry and biology of free radicals Development of synthetic methodology using copper, iron and ruthenium Functional Genomics / Chemical Genetics / Interactomics Use of plants in renewable plastics manufacture

  2. Recent Developments in Heterocycle Synthesis via Atom Transfer Radical Cyclisation Dr. Andrew Clark Chemistry Department, University of Warwick Coventry, UK +44 24 76523242 msrir@csv.warwick.ac.uk

  3. Atom Transfer Radical Cyclisation H. Nagashima et al, Tetrahedron Lett.,1983, 24, 2395 A. J. Clark, Chem. Soc. Rev.,2002, 31, 1

  4. H. Nagashima et al, J. Org. Chem.,1993, 58, 464

  5. A. J. Clark, D. Duncalf, R. P. Filik, D. M. Haddleton, G. H. Thomas, H. Wongtap, Tet. Letts,1999, 40, 3807

  6. Steric Effect of N-Substituent de = 54% de = 44% de = 2% de = 34%

  7. Relative rate versus ligand equivalence Toluene A. J. Clark, F. De Campo, R. J. Deeth, R. P. Filik, S. Gatard, N. A. Hunt, D. Lastecoueres, G. H. Thomas, J-B. Verlhac, H. Wongtap, J. Chem. Soc., Perkin 1, 2000, 671

  8. D. M. Haddleton, D. J. Duncalf, D. Kukulj, M. C. Crossman, S. G. Jackson, S. A. F. Bon, A. J. Clark, A. J. Shooter, Eur. J. Inorg. Chem. 1998, 1799 D. M. Haddleton, A. J. Clark, D. J. Duncalf, A. M. Heming, D. Kukulj, A. J. Shooter , J. Chem.Soc., Dalton Trans,1998, 381

  9. A. J. Clark, F. De Campo, R. J. Deeth, R. P. Filik, S. Gatard, N. A. Hunt, D. Lastecoueres, G. H. Thomas, J-B. Verlhac, H. Wongtap, J. Chem. Soc., Perkin 1, 2000, 671

  10. A. J. Clark, J. V. Geden, and S. Thom. J. Org. Chem., 2006, 71, 1471

  11. Ligand Acceleration

  12. Solid Supported Catalysts for ATRC A. J. Clarket al, J. Org. Chem., 1999, 64, 8954

  13. Kinetics to 80% Conversion (PS-PMDETA.CuCl) Ln([Ao]/[A]) Time (hrs) A. J. Clark, J. V. Geden, and S. Thom. J. Org. Chem., 2006, 71, 1471

  14. F. Ghelfi et al, Tetrahedron.,1997, 41, 1403

  15. A. J. Clark, G. M. Battle, A. Bridge, Tet. Letts., 2001, 42, 1999.

  16. A. J. Clark, C. P. Dell, J. M. Ellard, N. A. Hunt, J. P. McDonagh, Tet. Letts.,1999, 40, 8619

  17. A. J. Clark, C. P. Dell, J. M. Ellard, N. A. Hunt, J. P. McDonagh, Tet. Letts.,1999, 40, 8619

  18. A. J. Clark, C. P. Dell, J. P. McDonagh, C. R. Acad. Sci. Ser IIc: Chim, 2001, 4, 575

  19. Application to natural product synthesis

  20. A. J. Clark, J. V. Geden, S. Thom, J. Org. Chem., 2006, in preparation

  21. A. J. Clark, G.M. Battle, A. Bridge, Tetrahedron Letts.,2001, 42, 4409

  22. A. J. Clark, C. P. Dell, J. M. McDonagh, J. Geden, P. Mawdsley, Org. Letts., 2003, 5, 2063

  23. Cyclisation in ionic liquids

  24. Further Application of Solid Supported Catalysts

  25. Unhindered phenols Control Ortho substituted hindered phenol

  26. A. J. Clark, M. C. Crossman, D.Duncalf, D. M. Haddleton,S. R. Morsley, A. J.Shooter, J. Chem.Soc., Chem Commun., 1997, 1734

  27. Catalyst complex in water 25°C (Cu : ligand = 1 : 3)

  28. Catalyst Complex in water at 50°C

  29. 5-ExoCyclisation

  30. Five cyclisation products isolated; 6-endo (A and B) and 5-exo(C, D and E) • Ratio A : B : C : D : E = 6.5 : 4.5 : 4.5 : 1.8 : 1.0 : (crude 1H NMR) • NMR experiments have confirmed relative stereochemistry of C and D • Ratio 6-endo : 5-exo= 1.5 : 1 (crude 1H NMR) = 2 : 1 (isolated)

  31. 6-EndoCyclisation

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