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Pyrogens are lipopolysaccharides, in which the lipid part is pyrogenic in nature and the polysaccharide part increases the solubility of the pyrogen. Pyrogens are fever-inducing substances and are the products of metabolism of bacteria and viruses. However, it is the gram-negative bacteria that produce the most potent pyrogen.
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PyrogenTestingMarket:GlobalIndustryAnalysisandForecast2014-2020PyrogenTestingMarket:GlobalIndustryAnalysisandForecast2014-2020 PersistenceMarketResearch PyrogenTestingMarket:GlobalIndustry AnalysisandForecast2014-2020 1 PersistenceMarketResearch
PyrogenTestingMarket:GlobalIndustryAnalysisandForecast2014-2020PyrogenTestingMarket:GlobalIndustryAnalysisandForecast2014-2020 PersistenceMarketResearchReleasedNewMarketReporton“PyrogenTestingMarket: GlobalIndustryAnalysisandForecast2014-2020”. Pyrogensarelipopolysaccharides,inwhichthelipidpartispyrogenicinnatureandthepolysaccharide partincreasesthesolubilityofthepyrogen.Pyrogensarefever-inducingsubstancesandaretheproducts ofmetabolismofbacteriaandviruses.However,itisthegram-negativebacteriathatproducethemost potentpyrogen.Pyrogencontaminationcanoccurduetoenvironmentalfactors,andthrough contaminatedsolute,solvent,apparatus,andcontainer.Thehumanbodyiscapableoffightingthe bacterialtoxinsitisexposedtointheenvironmentthroughtheskin.However,whencontaminateddrugs areinjectedintothebloodstream,thetoxinsbypassnormaldefensemechanisms.Insuchasituation,the whitebloodcellspresentinthebodystartreleasinganotherformofpyrogenthatcauseshighfever,which incertaincasesmayleadtoshockanddeath.Riseinbodytemperature,chills,bodyaches,riseinarterial bloodpressure,andcutaneousvasoconstrictionaresomeofthereactionscausedinthehumanbody followingtheinjectionofharmfulpyrogens.Pharmaceuticalcompaniesusepyrogentestingtodetermine thepresenceofbacterialtoxinsinmedicalandveterinaryproducts.Thisprocesshelpstodetectthe presenceofmicrobesortheirmetabolitesinintravenoussolutionsduringmanufacturingoperations.The mostcommonandoldestformofpyrogentestingisinjectingdrugsintorabbits.Duringthisprocess,the substanceisinjectedintotherabbit’seartodetermineifthefeveroccurs.Therabbitpyrogentestis commonlyconductedtodetectthepossibilityofpyrogencontaminationininjectablepharmaceuticals. However,therabbitpyrogentesthassomelimitations.LimulusAmebocyteLysate(LAL)test,abacterial endotoxintest,isalsousedtodetectpyrogens.Thistestiscarriedoutonpharmaceuticalproductsused inparenteraldosageform,bloodproductsandplasmafractions,vaccines,nebulizersusedinrespiratory therapy,andforthevalidationofdryheatsterilization.However,LALtestismoreadvantageousthanthe rabbitpyrogentestasitislesstimeconsuming,moresensitive,lessexpensive,andeasiertoperform. BuyFullReport:http://www.persistencemarketresearch.com/market-research/pyrogen-testing- market.asp NorthAmericadominatestheglobalmarketforpyrogentestingduetoanincreasingnumberofnew biologicsorbiologicalproductsintheregion.Asiaisexpectedtowitnesshighgrowthratesinthenextfive yearsintheglobalpyrogentestingmarket,withChinaandIndiabeingthefastest-growingmarketsinAsia Pacific.Thekeydrivingforcesforthepyrogentestingmarketindevelopingcountriesarethelargepoolof patients,andincreasinggovernmentsupportforpharmaceuticalandbiotechnologyindustriesinthe region. 2 PersistenceMarketResearch
PyrogenTestingMarket:GlobalIndustryAnalysisandForecast2014-2020PyrogenTestingMarket:GlobalIndustryAnalysisandForecast2014-2020 Growingnumberofnewdruglaunches,rapidgrowthinpharmaceuticalandbiotechnologyindustries, increasingR&Dinvestmentsinlifesciences,andincreasinggovernmentsupportforpharmaceuticaland biotechnologyindustriesaresomeofthekeyfactorsdrivingthegrowthoftheglobalpyrogentesting market.However,highdegreeofconstraintsinpharmaceuticalindustryismajorrestraintonthegrowthof theglobalpyrogentestingmarket. Increasingpharmaceuticaloutsourcingactivitiesinthepharmaceuticalindustrywouldprovidemore opportunitiesfortheglobalpyrogentestingmarket.Transitionfromanimal-basedtestingtoin-vitrotestingisthetrendintheglobalpyrogentestingmarket.Themajorcompaniesoperatingintheglobalpyrogen testingmarketareAssociatesofCapeCod,Inc.,LonzaGroup,CharlesRiverLaboratoriesInternational, Inc.,Merck&Co.,Inc.,WakoChemicalsUSA,Inc.,EllabA/S,GenscriptUSAInc.,ThermoFisher Scientific,Inc.,Sigma-AldrichCorporation,andHyglosGmbh. RequestFullTOC:http://www.persistencemarketresearch.com/toc/4259 Keypointscoveredinthereport:- 1. Reportsegmentsthemarketonthebasisoftypes,application,products,technology,etc (asapplicable) Thereportcoversgeographicsegmentation NorthAmerica Europe Asia RoW Thereportprovidesthemarketsizeandforecastforthedifferentsegmentsand geographiesfortheperiodof2010to2020 Thereportprovidescompanyprofilesofsomeoftheleadingcompaniesoperatinginthemarket Thereportalsoprovidesportersfiveforcesanalysisofthemarket. 2. 3. 4. 5. Browsethefull“AllUpcomingPersistenceMarket's”reportat http://www.persistencemarketresearch.com/forthcoming-reports.asp AboutUs: PersistenceMarketResearchisaglobalmarketresearchfirmspecializing-syndicated research,customresearch,andconsultingservices 3 PersistenceMarketResearch
PyrogenTestingMarket:GlobalIndustryAnalysisandForecast2014-2020PyrogenTestingMarket:GlobalIndustryAnalysisandForecast2014-2020 AtPersistenceMarketResearch(PMR),weareinthebusinessofacceleratingyourbusiness. Asafull-servicemarketresearchfirm,westandcommittedtobringingmoreaccuracyandspeedtoyourbusinessdecisions.Fromready-to-purchasemarketresearchreportstocustomizedglobalresearchsolutions,ourengagementmodelsarehighlyflexiblewithoutcompromisingonourdeep-seatedresearchvalues.Brieflystated,ourmissionistogiveyouaccesstoforecastsandtrendsanalysesthatputyouonthepathtoprofitability. PMR’sServicesGoBeyondGleaningData: MostenterprisesbelievethatITanddatabasesareenoughtomakeanaccuratedecision.Whilewedonotdisputethat,considerthis:Howlongdoesittaketomakeanaccurateandstrategicmillion-dollardecision?Westrivetodeliverbothevenwithdemandingdeadlines. FacilitatingRapidandInformedBusinessDecisions PMRwasfoundedwithonegoalinmind:toofferenterprisesatangiblebusinessadvantagebycarefullybalancingtraditionalandmodern-dayresearchmethodologies. ContactUs: AddieThomes 305Broadway, 7thFloor, NewYorkCity,NY10007,UnitedStates. Phone:+1-646-568-7751 USA/CanadaTollFreeNumber. 1-800-961-0353 E-mail:Sales@persistencemarketresearch.com Web:http://www.persistencemarketresearch.com/ 4 PersistenceMarketResearch