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Interpenetrating Networks for Delivery Systems. Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering Advisor: Professor Naomi Chesler, Department of Biomedical Engineering Ashley Huth Claire Flanagan Adam Rieves Jon Sass. Overview. Background Information
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Interpenetrating Networks for Delivery Systems Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering Advisor: Professor Naomi Chesler, Department of Biomedical Engineering Ashley Huth Claire Flanagan Adam Rieves Jon Sass
Overview • Background Information • Interpenetrating Networks (IPNs) • Competing Products • Past Semester • Problem Statement • Design Requirements • Proposed Designs • Future Work • Questions
Problem Statement • To design a novel delivery mechanism to reconstitute the components of an interpenetrating network (IPN).
*Kao, W.J. Conventional Dressings IPN Irregular Wound Background: IPNs • What is an IPN? • A bioactive wound dressingfor • large surface area wounds
Kao, W.J. Covalently Linked Therapeutic(s) and/or Cell Adhesion Ligands Biodegradable Gelatin Backbone PEG-diacrylate (2-3.4 kDa ) Soluble Therapeutic(s) in situ UV curing Background: IPNs IPNs are composed of multiple components Solution (drugs + matrix component)
Clinical Application • Benefits • Biocompatible • Moist healing environment • Conforms to irregular wounds • Covers large surface area wounds • Delivers drug cocktails • Issues • Heat • Uneven administration • Lengthy application process
Day 7 Day 3 Day 1 Current Administration Technique 1 Mix Ingredients/ drug(s) in single container 2 Heat • Components • pegDA • Gelatin • Photoinitator • Water Inject Syringe is use to administer solution 3 4 Cure in 30 sec to obtain a rubbery film 7 Clean 6 Sustained Release while the IPN biodegrades 5 Cover *Kao, W.J
Last Semester • Focused on optimizing IPN solution composition • Gelatin dissolution impacts efficacy & administration of IPNs • Integrated laboratory & design-based research • Developed IPN recipe • Modified IPN administration This Semester • Administration technique • Product packaging • Further laboratory research
Design Requirements • Minimal preparation and effort required to administer the IPN • Compartmentalization • Even spray pattern • Uniform solution • Straightforward mixing procedure • Disposable • Can be sterilized • Low-cost • Few parts
Competing Products • Duoject Medical Systems Inc. • Inter-Vial • Debiotech • Clip’n’ject • U-Mix • Travel Bottle • Hansplast • Spray Bandage
Design 1: Syringe • Liquid in plunger • Powder stored in barrel • Mechanism to release liquid into powder • Hand mixing • Hand powered delivery • Luer-Lock spray tip
Design 1: Syringe • Pros • All in one packaging • Easy application • Controllable spray rate • Cons • Custom manufacturing required • Moving parts
Design 2: Pressurized Bottle • Manual pressure vacuum • Unique cap design • Facilitates stirring mechanism • Perforated seal
Design 2: Pressurized Bottle • Pros • Parts readily available • Few modifications necessary • Spray is sustained for approx. 20 sec • Cons • Pressure building is laborious • All parts must be packaged separately • Pressure feature comes at a cost ($14) • Only one size is available
Design 3: Spray Bottle • Threaded straw • Blades puncture inner container • Single pump, single spray • Includes mixing mechanism
Design 3: Spray Bottle • Pros • Incorporates mixing mechanism • Provides slow release of photo-initiator • Cons • Laborious application technique • Non-standard parts
Future Work • Test cold-water soluble gelatin • Develop-Manufacture-Test prototype • Research photoinitiators • Continue patent search