1 / 16

Neuroinformatics

Neuroinformatics. Maryann Martone Amarnath Gupta. Bioinformatics. a scientific discipline that encompasses all aspects of biological information acquisition, analysis and interpretation combines tools and techniques of mathematics, computer science and biology

victoir
Download Presentation

Neuroinformatics

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Neuroinformatics Maryann Martone Amarnath Gupta

  2. Bioinformatics • a scientific discipline that encompasses all aspects of biological information acquisition, analysis and interpretation • combines tools and techniques of mathematics, computer science and biology • depends on large stores of both experimental and derived data

  3. Challenges • Total amount of data (e.g., 250,000 new articles per year) • Complexity of data and lack of standardization • Lack of general-purpose, interoperable tools • Lack of automation

  4. Information Paradox Too much data Too little data

  5. “Understanding brain function requires the integration of information from the level of the gene to the level of behavior. At each of these many and diverse levels there has been an explosion of information, with a concomitant specialization of scientists. The price of this progress and specialization is that it is becoming virtually impossible for any individual researcher to maintain an integrated view of the brain and to relate his or her narrow findings to this whole cloth.” -Stephen Koslow

  6. technique species discipline modality Organism Cells Molecules

  7. Too little information: -missing information -information that was known at one time but lost -information that may not be explicit -information was known but not recorded -information contained in images, traces etc.

  8. Publication Data Specimen Instrument Images Traditional Method of Data Collection and Presentation

  9. Human Brain Project: Moving towards an information-centric approach to Neuroscience Specimen Instrument Images Publication Data Database

  10. Information-centric Neuroscience Specimen Instrument Images Data Information Sources .Database .Literature .Web sites

  11. Two Research Efforts: • Development of a 3D Cell-centered database. Human Brain Project • Federation of Brain Data: National Partnership for Advanced Computational Infrastructure

  12. Topics • Intro to Bioinformatics • Databases • Data modeling • Brain imaging • Neuronal modeling • Data integration

  13. Structure of Course • Weekly seminar • Articles or exercises • Class discussion • Short paper on neuroinformatics approaches to your own research http://ncmir.ucsd.edu/NCDB/

More Related