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Why does C increase so slowly even when A is the only other allele?

Why does C increase so slowly even when A is the only other allele?. AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA C AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA When C is a new allele. Genotypes: AA AC

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Why does C increase so slowly even when A is the only other allele?

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  1. Why does C increase so slowly even when A is the only other allele? • AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA • When C is a new allele • Genotypes: • AA • AC • CC has the highest fitness, but it will increase in frequency slowly as few couples both carry the C allele to have CC babies

  2. Why does C increase even more slowly if S is present? • AAAAAAAASAAASAAAAAAAAAAAAAAAAAAAAAAAASAAAAAASAAAASAAAAAAACAAAAAAAAAAAAASAAAAASAAAASAAAAASAAASAAASAAAAA • When C is a new allele • When S = 0.12 • Genotypes: • AA (0.90) • AS (0.985), AC (0.954) • CC has the highest fitness, but it will increase in VERY frequency slowly as few couples both carry the C allele to have CC babies • AND because the fitness differential is smaller (selection is weaker since AS and AC have nearly equal fitness)

  3. Selection pressure: Intense vs. weakDepends on fitness differentials

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