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U.S. Influenza Surveillance. Lisa Grohskopf, MD, MPH Medical Officer Influenza Division Centers for Disease Control and Prevention. National Center for Immunization & Respiratory Diseases. Influenza Division. VRBPAC Meeting February 25, 2011.
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U.S. Influenza Surveillance Lisa Grohskopf, MD, MPH Medical Officer Influenza Division Centers for Disease Control and Prevention National Center for Immunization & Respiratory Diseases Influenza Division VRBPAC Meeting February 25, 2011
Characteristics of Recent Influenza Viruses Tested at CDC Of 644 U.S. viruses antigenically characterized at CDC since October 1, 2010: • 85 (13%) Influenza A (H1N1) • 85 (100%) A/California/7/2009-like • 348 (54%) Influenza A (H3N2) • 345 (99%) A/Perth/16/2009-like • 211 (33%) Influenza B • 199 (94%) Victoria lineage; 198 (99%) B/Brisbane/60/2008-like • 12 (6%) Yamagata lineage High level resistance to adamantanes persists among Influenza A isolates; A(H1N1), A(H3N2) and B virus isolates tested remain susceptible to neuraminidase inhibitors
Percentage of Visits for Influenza-like Illness (ILI) Reported by the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet), Weekly National Summary, September 30, 2007 – February 12, 2011
Influenza Positive Tests Reported to CDC by U.S. WHO/NREVSS Collaborating Laboratories, National Summary, 2010-11 Number of Positive Specimens Percent Positive
Pneumonia and Influenza Mortalityfor 122 U.S. CitiesWeek Ending 02/12/2011 EpidemicThreshold SeasonalBaseline 2006 2007 2008 2009 2010 2011
Deaths Reported Previous Week Deaths Reported Current Week Number of Influenza-Associated Pediatric Deaths by Week of Death: 2007-08 season to present 2009-10 Number of Deaths Reported = 282 2010-11 Number of Deaths Reported = 35 2008-09 Number of Deaths Reported = 133 2007-08 Number of Deaths Reported = 88
Key Points • Influenza A(H3N2), A(H1N1), and B strains continue to co-circulate in the U.S. • Recently characterized strains appear to be well-matched to the recommended 2010-2011 seasonal vaccine • Recently circulating viruses remain susceptible to neuraminidase inhibitors • In the U.S., influenza activity remains high in recent weeks • Increase in proportion of influenza A viruses identified as A(H1N1) since the beginning of the U.S. season