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Topics to Cover This Lecture. What is anesthesia"History and mechanism of anesthesiaUptake and distribution of inhaled anestheticsCNS effects of anesthesiaMinimal alveolar concentration (MAC)Properties of inhaled anestheticsSystem effects of inhaled anestheticsDelivery systems for inhaled an
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1. What is Anesthesia? Franklin Scamman, MD
2. Topics to Cover This Lecture What is “anesthesia”
History and mechanism of anesthesia
Uptake and distribution of inhaled anesthetics
CNS effects of anesthesia
Minimal alveolar concentration (MAC)
Properties of inhaled anesthetics
System effects of inhaled anesthetics
Delivery systems for inhaled anesthetics
3. “Anesthesia” Insensitivity to pain
May be from local or general agents
Term introduced by Oliver Wendell Holmes in 1847 in response to work by WTG Morton using ether
4. History of Anesthesia Greeks and Romans: aware of opium and derivatives; oral ethanol
Japan: 1820s, mandrake causing cholinergic crisis and unconsciousness
TWG Morton, MGH, October 16, 1846 using diethyl ether
However, Crawford Long in 1849 described his use of it in 1842
5. MGH “Ether Dome” 1846