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Integration of Metabolism

Integration of Metabolism. Jack Blazyk 3/4/04. Well-Fed Conditions. Only in America. Glycogenesis. Well-Fed Liver. Glycolysis. Cholesterol Synthesis. Pentose Shunt. Triglyceride Synthesis. Fatty Acid Synthesis. Well-Fed Adipose. Pentose Shunt. Glycolysis. Cholesterol Synthesis.

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Integration of Metabolism

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  1. Integration ofMetabolism Jack Blazyk 3/4/04

  2. Well-FedConditions

  3. Only in America

  4. Glycogenesis Well-Fed Liver Glycolysis Cholesterol Synthesis Pentose Shunt Triglyceride Synthesis Fatty Acid Synthesis

  5. Well-Fed Adipose Pentose Shunt Glycolysis Cholesterol Synthesis Triglyceride Synthesis Fatty Acid Synthesis

  6. Well-Fed Muscle Glycogenesis

  7. Glucose Insulin Glycogen CO2 + H2O Glucose Glucose aa aa CO2 + H2O Urea Protein Chylomicrons Pyruvate TG TG VLDL CO2 + H2O Lactate Glycogen Lactate Well-Fed State Brain Pancreas Gut Portal Vein Liver Adipose Lymphatics Muscle RBC

  8. FastingConditions

  9. Glycogenolysis Fasting Liver Gluconeogenesis Ketone Body Synthesis Fatty Acid Oxidation

  10. No Uptake Fasting Adipose Triglyceride Breakdown Fatty Acid Oxidation

  11. No Uptake Fasting Muscle Ketone Body Utilization Fatty Acid Oxidation

  12. Glucose Glucagon Glycogen CO2 + H2O Glucose FA Pyruvate FA CO2 + H2O CO2 + H2O Lactate Lactate Early Fasting State Brain Pancreas Gut Portal Vein Adipose Liver Lymphatics Muscle RBC

  13. Glucagon CO2 + H2O Glucose KB Glycerol Urea FA FA CO2 + H2O Pyruvate CO2 + H2O aa Protein Cortisol Lactate Extended Fasting State Brain Pancreas Gut Portal Vein Adipose Liver Lymphatics RBC Muscle

  14. Glucose Insulin Glycogen CO2 + H2O Glucose Glucose aa aa CO2 + H2O Urea Protein Chylomicrons Pyruvate TG TG VLDL CO2 + H2O Lactate Glycogen Lactate Well-Fed State Brain Pancreas Gut Portal Vein Liver Adipose Lymphatics Muscle RBC

  15. Glucagon CO2 + H2O Glucose KB Glycerol Urea FA FA CO2 + H2O Pyruvate CO2 + H2O aa Protein Cortisol Lactate Extended Fasting State Brain Pancreas Gut Portal Vein Adipose Liver Lymphatics RBC Muscle

  16. Useful Endocrine & Metabolism Link http://arbl.cvmbs.colostate.edu/hbooks

  17. Malonyl-CoA CoA-SH Cytoplasm Carnitine Shuttle CoA-SH Matrix O O = = CH3-(CH2)14-C-S-CoA CH3-(CH2)14-C-S-CoA Regulation X

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