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Activity Goals

Individualizing Therapy for Patients With CLL in the Community Practice Setting: Focus on Age and Comorbidities. Activity Goals. Extended Follow-up CLL8 (GCLLSG). CLL5 Protocol: Overall Survival. PFS in Patients > 70 y: Across Treatment Regimens.

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Activity Goals

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Presentation Transcript

  1. Individualizing Therapy for Patients With CLL in the Community Practice Setting:Focus on Age and Comorbidities

  2. Activity Goals

  3. Extended Follow-up CLL8 (GCLLSG)

  4. CLL5 Protocol: Overall Survival

  5. PFS in Patients > 70 y: Across Treatment Regimens

  6. Fludarabine (F) vs Chlorambucil (Ch) by Age Group < or > 65 y

  7. PFS: Ch vs Bendamustine (B) in Untreated CLL

  8. Ch + Rituximab (R) in Symptomatic, Previously Untreated CLL

  9. Ch + R in Symptomatic, Previously Untreated CLL

  10. Targeting of BCR Signaling With Ibrutinib

  11. Phase 2 (PCYC-1102-CA) in CLL/SLL

  12. Phase 2: Best Response by Risk Features

  13. Phase 2: PFS

  14. Phase 2: PFS by Prognostic Factors

  15. Ibrutinib and Rituximab (IR) in High-Risk CLL

  16. Transient Lymphocytosis on IR in High-Risk CLL

  17. Lymph Node Responses Assessed by CT (31 Evaluable Patients)

  18. Idelalisib + Rituximab in Frontline CLL

  19. Nodal Response: Idelalisib + Rituximab

  20. Response: Idelalisib + Rituximab

  21. PFS: Idelalisib + Rituximab

  22. Conclusions

  23. Abbreviations

  24. Abbreviations (cont)

  25. References

  26. References (cont)

  27. References (cont)

  28. References (cont)

  29. References (cont)

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