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INTRODUCTION

INTRODUCTION. Malaria is weidly known human disease. Caused by infection with pathogenic protozoan parasite of blood, the Plasmodium . female Anopheles mosquitoes transmit P lasmodium from person to person Serving as carrier host

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INTRODUCTION

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  1. INTRODUCTION • Malaria is weidly known human disease. • Caused by infection with pathogenic protozoan parasite of blood, the Plasmodium. • female Anopheles mosquitoes transmit Plasmodium from person to person • Serving as carrier host • Drives certain proteins from human blood, important in egg formation.

  2. Distribution :-cosmopolitan parasite, wide-spread in tropical and temperate countries. • Habitat :- Endoparasite, found in blood of man, also found in alimentary canal and salivary glands of female Anopheles mosquitoes. • Habits :- Intracellular parasite.

  3. LIFE CYCLE

  4. ASEXUAL CYCLE AND SCHIZOGONY IN MAN • Life cycle of plasmodium in man consist of two phase: • Exoerythrocytic or hepatic schizogony • Erythrocyctic schizogony

  5. EXOERYTHROCYTIC SCHIZOGONY • Inoculation or Infection. • Structure of sporozoites. • Liver schizogony. • Pre- erythrocytic phase. • Exo- erythrocytic phase. • Pre-patent and incubation periods.

  6. ERYTHROCYTIC SHIZOGONY • Includes following stages • Trophozoite stage. • Signet ring stage. • Amoeboid stage. • Schizoint. • Formation of gametocytes

  7. SEXUAL CYCLE OF PLASMODIUM IN MOSQUITO • Development of gametocyte in the mosquito stomach involve two important events. • Sexual cycle • sporogony • Sexual cycle a. Gametogenesis :- Formation of male gametes Formation of female gametes

  8. b. Fertilization:- cone of reception is formed. Male gamete penetrates the female gamete through this cone. Gametes fuse to form diploid zygotic nucleus or synkaryon. Zygotes formed in stomach of mosquito about 9 or 10 days after the blood meal. c. Ookinete :-zygote start elongating and undergoes changes and becomes 15-20 micro meter and 3micro meter thick, worm like motile organism called vermicule or ookinete. Becomes enclose in cyst. Encysted zygote is called oocyst.

  9. SPOROGONY • Oocyst undergoes asexual multiplication known as sporogony. • Nucleus divides by mitosis, forming about 10,000 daughter nuclei, within 2-3 days. • Spindle shaped body is formed called sporozoites.

  10. Thank You

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