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Medication Adherence:. To Take or Not To Take?. Adherence vs. Compliance . Adherence : “the degree to which a person’s behavior coincides with medical advice” Adherence requires the patient’s agreement with the recommendations
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Medication Adherence: To Take or Not To Take?
Adherence vs. Compliance • Adherence: “the degree to which a person’s behavior coincides with medical advice” • Adherence requires the patient’s agreement with the recommendations • Compliance may suggest a passive approach by the patient to health care
Persistence • Overall duration of drug therapy • The interval between date of first Rx and point where patient would have insufficient supply of drug to cover days between Rx refills NEEDED: Hybrid Term • Defines patient’s medication-taking behavior in terms of both duration & intensity
What is the most common type of dosing error? • Dose omission • Extra dose taken • Misscheduled dose • Incorrect dosage
How Much is Enough? • “Adequate Adherence” • Drug & disease dependent • Most researchers use 80%
Lets Look at the Numbers • 14% of all written prescriptions are never filled • 13% are filled but never taken • Chronic diseases: • Adherence drops most dramatically after first 6 months • 50% drop out of treatment • Of those who continue, typical rates of adherence are 50 to 60%
Patients with which of the following diseases or conditions are most likely to adhere to their medications? • Diabetes • HIV • Seizure disorders • Organ transplant
What are the Consequences? • Causes 125,000 deaths annually • 10% of hospital and 23% of nursing home admissions are linked to nonadherence • Nonadherence directly costs the US health care system $100 billion annually • Annual indirect costs exceed $1.5 billion in lost patient earnings and $50 billion in lost productivity
Adherence Post MI Hospitalization Evaluated 1521 patient’s use of ASA, beta blockers & statins one month post hospitalization Patients who discontinued use of all medications had lower 1 year survival (88.5% vs 97.7%) compared with those taking 1 or more of the medication
Adherence Rates & BP Control • Retrospective evaluation of >10,000 pt with coronary disease, followed a mean of 4.6 years • Investigated causes of treatment failures • 1/3 of cases: failure to intensify treatment • 1/3 of cases: medication nonadherence • 67% did not fill Rx despite therapy intensification • Conclusion: Importance of communication between clinician & pt Arch Intern Med.2008;168(3):271-76
Evaluating Adherence • How accurate are physician’s estimates of their own patient’s adherence? • 80% • 75% • 60% • 50%
Evaluating Adherence:Pill Counts • Counting the number of remaining dosage units at clinic visits • Advantages: • Easy • Inexpensive • Objective • Disadvantages: • Patient must bring in all medications at each visit • Does not capture information such as timing of doses & patterns of missed doses • Patients can scam the system
Evaluating Adherence:Monitoring Pharmacy Databases • Check when prescriptions are initially filled, refilled over time & prematurely discontinued • Advantages: • Relatively easy • Relatively inexpensive • Objective • Disadvantages: • Obtaining a prescription does not ensure its proper use • Information data base may be incomplete
Evaluating Adherence:Patient Self-Report • Patients can be accurate in reporting whether they are adhering to their medication treatment if they are asked simply & directly • Advantages: • Practical, easy • No cost • Disadvantages • All patients may not be forthcoming • Susceptible to error with increasing time between visits
Which of the following questions is likely to elicit a honest response? • “You are taking all of your pills, aren’t you?” • “Many people have difficulty taking their medications as prescribed. Do you have any problems taking your meds?” • “I know it is very difficult to remember to take medications on a daily basis. How often did you forget to take your (specific drug name) last week?”
Evaluating Adherence:Surrogate Markers • Appointment records • Physical assessment & laboratory monitoring
This I Know… • There is no gold standard for measuring adherence behavior • Use a multi-method approach that combines self-reporting and reasonable objective measures
Five Dimensions of Adherence Health system Social/economic factors factors Condition related Therapy related factors factors Patient related factors
Social & Economic Factors • Poor socioeconomic status • Illiteracy • Age • Race • Lack of effective social support networks • Family dysfunction • Culture & lay beliefs about illness & treatment • Cost of medication & health care
Health Care Team & System Related Factors • Patient-provider relationship • Level of and accessibility to health services (convenience factors) • Cost issues • Level of knowledge & training for health care providers on chronic disease management • Lack of knowledge on adherence & of effective interventions for improvement • Lack of incentives & feedback on performance in this area
Condition Related Factors • Rate of progression & severity of the disease • Severity of symptoms • Level of disability • Availability of effective treatments • Co-morbidities such as depression & alcohol abuse
Therapy Related Factors • Complexity of the medication regimen • Duration of treatment • Previous treatment failures • Frequent changes in treatment • Immediacy of beneficial effects • Adverse effects • Cost
Patient Related Factors • Knowledge about the disease and its management • Confidence in diagnosis and ability to engage in illness-management behaviors • Self-perceived need for treatment and consequences of poor adherence • Psychosocial stress • Expectations
This I Know… • Patients have many barriers facing them when it comes to taking their medications as prescribed • There are no definitive predictors of nonadherence • Every patient should be viewed as a potential poor adherer
Based on self report, what is the most common reason patients gave for not taking their medications as prescribed? • Cost • Forgetfulness • Adverse side effects • Not convinced of the need & value of the therapy
Strategies to Improve Adherence • The entire health care system as well as patients need to better understand the clinical value of medication adherence & persistence
Strategies to Improve Adherence • Therapy Related Interventions • Patient Related Interventions
Therapy Related Interventions • Simplify the regimen • Adherence declines significantly as the dosing frequency exceeds twice a day • Combination products reduce the number of doses per day as well as patient copayments • Help patient organize all medications and establish an administration schedule • Match administration times to patient’s activities of daily living
Therapy Related Interventions • Periodic medication profile review • Systematic, ongoing review of all medications • Ensure patient is on the fewest medications possible
Therapy Related Interventions • Minimize the occurrence & impact of adverse effects • Educate patients about the most common adverse effects associated with the medication • Inform patients if adverse effects do occur it is usually possible to modify therapy to eliminate or avoid the unintended effects • Ask patients if they are experiencing any possible adverse effects • “Are you experiencing any problems taking your medications?” • “Do your medications make you feel bad in any way?”
What % of patients reported not taking their medications due to concerns about ADRs? • 10% • 25% • 45% • 50%
Patient Related Interventions • Major barriers: • Lack of information & skills regarding self management • Difficulty with motivation & self-efficacy • Lack of support for behavioral changes
Impart Information • Components of patient education • Knowledge • Skill • Attitude
Patients typically forget what % of the info from a verbal explanation immediately after they heard it? • 10% • 25% • 50% • 75%
Physician Communication When Prescribing New Medications • Goal: assess quality of physician communication with patients about newly prescribed medications • Methods: observational study of transcribed audiotaped office visits from 185 outpatient encounters • Results: • % of times MD stated: • Medication name = 74% • Purpose of med = 87% • ADRs = 35% • How long to take med = 34% • # of tablets to take = 55% • Frequency or timing of dosing = 58% Arch Intern Med. 2006;166:1855-1862.
True or False? Once I tell my patients it is the right thing to do, they will adhere to their medications as prescribed.
Motivation & Self-Efficacy • Directive method of communicating to enhance a person’s intrinsic motivation to change by exploring & resolving ambivalence & resistance • Goal: increase the chance the patient will engage in healthy behaviors by uncovering the patient’s actual needs
Creating a Favorable Climate for Change • The patient must: • Recognize there is a problem (perceived susceptibility) • Believe the medical condition to be serious (perceived severity) • Believe that the prescribed medication will help correct the problem (perceived benefits) • Understand how to use the medication & have confidence in their ability to do so (self-efficacy) • Have realistic expectations about the outcomes (cure vs control)
The “Iceberg Effect” WHAT YOUR PATIENT TELLS YOU WHAT YOUR PATIENT DOESN’T TELL YOU Full extent of adverse effects Lifestyle concerns Confusion and memory problems Disabilities Doubts and fears
Elicit the Patient’s Thoughts • Look for resistance • “How confident are you that this medication will help you?” • “What is your understanding of the consequences of not treating your (disease state)?” • “What is your overall goal in using this medication?”
Always ask: "What do you think will prevent you from carrying out the plan we agreeded upon?"
Support for Behavioral Changes • Dosing Reminders • Visual cues • Place the vial in a “trigger” location • Note on the refrigerator or bathroom mirror • Pill boxes / organizers • Mark the calendar or PDA • Computer pop-ups or alarms • Remindermed.com • Rxnotify.com
Support for Behavioral Changes • Reinforcement and Rewards • Routine reports on progress • Ongoing reinforcement of the importance of adherence • Praise • Vigilance effect
If a teacher gives a homework assignment but says you never have to turn it in and that he will never check it , what are the chances you will actually complete the assignment?