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CHAPTER 8

CHAPTER 8. STOCHASTIC. Random “all or nothing” linear,nonthreshold playing the lottery. Deterministic Effect. AKA nonstochastic or certainty effect Nonlinear threshold curve threshold assumed increases with severity of dose. Dose Linear Curves (PG 112 in Sherer, Pg.498-499 Bushong).

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CHAPTER 8

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  1. CHAPTER 8

  2. STOCHASTIC • Random • “all or nothing” • linear,nonthreshold • playing the lottery

  3. Deterministic Effect • AKA nonstochastic or certainty effect • Nonlinear threshold curve • threshold assumed • increases with severity of dose

  4. Dose Linear Curves (PG 112 in Sherer, Pg.498-499 Bushong) • Linear, non-threshold • Linear threshold • Nonlinear (Curvilinear, Sigmoid) Threshold curve • Non-linear, non threshold curve • Linear Quadratic Non threshold

  5. AGE • The age of the biological structure determines sensitivity • Bergonie and Tribondeau • Embryo-fetus-newborn-young child • Decreases in late teens • Stabilizes until old age • increases in old age

  6. RECOVERY • Cell can recover if sufficient time is given between irradiation • some cells have greater capacity for repair • Sufficient radiation causes atrophy

  7. REVIEWPRINCIPLES OFRADIOBIOLOGY ARE BUILT ON THE FOLLOWING:1)RANDOM NATURE2)RADIATION INTERACTS AT CELLULAR LEVEL3)FACTORS THAT ALTER THESE INTERACTIONS

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