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Fractal Approach to Genome Analytics Software for Personalized Healthcare

This software enables a fractal approach to genome-based economy and personalized healthcare systems, featuring the DNA/RNA system as a fractal genomic cerebellum.

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Fractal Approach to Genome Analytics Software for Personalized Healthcare

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  1. GENOME ANALYTICSSOFTWARE-ENABLING FRACTAL APPROACHTO A GLOBAL, GENOME-BASED ECONOMY, WITH PERSONALIZED HEALTH-CARE SYSTEMS Featuring the DNA / RNA System as a Fractal Genomic Cerebellum Andras J. Pellionisz Ph.D. in Computer Engineering, Ph.D. in Biology, Ph.D. in Physics bio President of HolGenTech, Inc. Silicon Valley, California company International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  2. Genomics is Informatics, 2002System Theory ? Fractal System ! FractoGene, 2002 Unification of Neuroscience and Genomics, 2012 International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  3. HoloGenome: a Fractal System – Pellionisz FractoGene, 2002 International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  4. Public Domain Fractal Rendering of Heart Coronaries, Lung FractoGene; seed-concept of recursion in Pellionisz 1989, USPTO priority Date Aug. 1st, 2002), 2005, 2008, Cold Spring Harbor, 2009, Springer Verlag 2012 International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  5. All Genomes are Fractal? The Indian DNA Certainly is… International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  6. 3D Hilbert-curve (“fractals” go back to Euler!) is • Ultra dense (fold 2m DNA into 6 micron nucleus) • Knot-free (for unhindered “pervasive transcription”) • “See through” (for maximal functional closeness of linearly remote fragmented genomic regions) Dr. Eric Schadt, CSO, PacBio, Mount Sinai (2011 Jan): “Of most interest to me are Andras Pellionisz’ ideas around the fractal nature of genomes and how disruptions in such structure may drive phenotypic variation… The detection of these structures and subsequent determination of their association with disease are computationally intense problems. If something like this were shown to be true (disruptions in the fractal structures lead to phenotypic change), it would be truly revolutionary”.  International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  7. Well, it has been shown to be true (by 2011 November) ! Independent Experimental Proof of Concept: Fractal Defect Causes Cancer ! High order chromatin architecture shapes the landscape of chromosomal alterations in cancer Geoff Fudenberg, Gad Getz, Matthew Meyerson & Leonid A Mirny Nature Biotechnology 29,1109–1113 (2011) doi:10.1038/nbt.2049 Abstract. The accumulation of data on structural variation in cancer genomes provides an opportunity to better understand the mechanisms of genomic alterations and the forces of selection that act upon these alterations in cancer. Here we test evidence supporting the influence of two major forces, spatial chromosome structure and purifying (or negative) selection, on the landscape of somatic copy-number alterations (SCNAs) in cancer. Using a maximum likelihood approach, we compare SCNA maps and three-dimensional genome architecture as determined by genome-wide chromosome conformation capture (HiC) and described by the proposed fractal-globule model. This analysis suggests that the distribution of chromosomal alterations in cancer is spatially related to three-dimensional genomic architecture and that purifying selection, as well as positive selection, influences SCNAs during somatic evolution of cancer cells. Link International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  8. High order chromatin architecture shapes the landscape of chromosomal alterations in cancerGeoff Fudenberg, Gad Getz, Matthew Meyerson & Leonid A MirnyNature Biotechnology 29,1109–1113 (2011) International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  9. Intact Fractality: The Ultra-Dense Genome is Functionally Transparent; Readable in Parallel Fractal Defect (of a Copy Number Alteration Here) Clogs Transparency; Disrupts “Functional Proximity”; the Result is Misregulation (Cancer) International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

  10. International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012)Hyderabad, India, by Pentagram Res. Ctr.

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