Appendix 1

1. A. B. mPPARa 18 hPPARa ** 20 ** ** ** ** ** 12 Relative reporter activity 15 Relative reporter activity 10 * 6 * 5 * 0 (-) WY Rosi GW CG269 0 1mM 1mM 1mM (-) WY Rosi GW CG269 1mM 1mM 1mM C. D. # PPARd LXR # 10 8 8 6 Relative reporter activity Relative reporter activity 6 4 4 2 2 0 0 (-) T1317 WY Rosi GW CG269 (-) WY Rosi GW CG269 E. EC 50 =39 nM 15 PPARa // 10 Relative reporter activity 5 // 0 0 0.001 0.01 0.1 1 10 (mM) F. 15 PPARg // // // 10 Relative reporter activity EC 50 =2.69 mM 5 0 0 0.001 0.01 0.1 1 10 (mM) Jeong et al. Appendix 1

2. Jeong et al. Appendix 2 A. B.

3. A. + + + + + + PPARa + WY GW + + Rosi CG269 + Trypsin + + + + + * * * * B. + + + + + + PPARg + WY GW + + Rosi CG269 + Trypsin + + + + + * * * * Jeong et al. Appendix 3

4. A. 8 # # * 6 * * * * 4 Relative gene expression * * 2 0 ACO CPT1 B. Jeong et al. Appendix 4 Fold of b-oxidation * 1.5 * 1.0 0.5 0 (-) WY Rosi CG269

5. A. 8 # # * * 6 * * * 4 Relative gene expression # # * * # * * * 2 0 aP2 Acrp30 LPL CD36 B. 3T3-L1 # # # # # # # * * * * * * * * 8 C. 6 4 # 4 3 Relative gene expression # # # * * Relative gene expression 2 2 1 0 aP2 Acrp30 LPL CD36 0 aP2 Acrp30 LPL 3T3-F442A WAT D. # Acrp30 aP2 CD36 * * * * ¶ * ¶ * * ¶ ¶ * ¶ ¶ # * # * * * Jeong et al. Appdneix 5 1.5 Veh WY PPARg Rosi CG269 1.0 Relative mRNA (-) Rosi (-) Rosi (-) Rosi CG269 CG269 CG269 0.5 0.0

6. A. B. 1 2 3 4 5 6 7 8 PmvK Upregulation Downregulation Mthfd1l Total 246 Iars Rosi 218 Agpat3 15 39 100 118 Hadhb Cfd 85 78 Ifi30 1 91 79 CxCl12 CG269 170 6 Retn Veh CG269 CG269 Rosi 0.5mM5mM1mM C. Jeong et al. Appendix 6

7. 10 8 6 Relative gene expression 4 2 0 TNFa IL-1b IL-6 iNOS MCP1 COX2 MMP9 3T3-F442A Jeong et al. Appendix 7 * ** # * * # * * # * # # ¶ ¶ # ¶ # ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶

8. 7.5 5.0 Average daily food intake (g) 2.5 0.0 Veh WY Rosi CG269 Jeong et al. Appendix 8

9. Jeong et al. Appendix 9 * * Relativegene expression * * * # *

10. Jeong et al. Appendix 10 Veh WY Rosi CG269