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Cross-institutional clinical federated querying in the CTSA consortium

Adapting the i2b2 Architecture to Support Cross-Institutional Clinical Translational Research. ?Information exchange environment" pilot project2008-20104 partnersUniversity of Washington ITHSUC San Francisco CTSIUC Davis CTSCRecombinant Data Systemswww.i2b2.orgwww.bioontology.orgwww.i2b2cic

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Cross-institutional clinical federated querying in the CTSA consortium

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    1. Cross-institutional clinical federated querying in the CTSA consortium

    2. Adapting the i2b2 Architecture to Support Cross-Institutional Clinical Translational Research �Information exchange environment� pilot project 2008-2010 4 partners University of Washington ITHS UC San Francisco CTSI UC Davis CTSC Recombinant Data Systems www.i2b2.org www.bioontology.org www.i2b2cictr.org (later this month)

    3. I2B2CICTR aims/phases Aim 1: (4 months) Establish a collaborative, information exchange and technical foundation by piloting a inter-institutional federated query system using test PHI data. Aim 2: (9 months) Build on this technical foundation by piloting a cohort discovery service of limited, anonymized PHI data across the three sites. Aim 3: (11 months) Extend the resolution of cohort data available to investigators by implementing an ontology-mapping tool at each institution to collectively pilot a inter-institutional �reference ontology�

    4. End-user needs and use-cases Clinical translational investigators Ability to determine if study subjects are available at local institution or within consortium Create queries to explore retrospective clinical data characteristics Ability to modify and reuse query criteria to reflect research process CTSA informatics and clinical IT staff Ability to lower resource of providing these services manually by developing high-level user-interface Ability to easily generate data in formats suitable for analysis Ability to capture re-occurring study queries and associated meta-data for modeling

    5. Driving use cases

    6. Phase 1: Technical interoperability

    7. Phase 2: Pilot Anonymous aggregate cohort discovery sss

    8. Phase 3: Pilot complex semantic data

    9. Source data systems

    10. Four parallel processes Technical group - IT/development/testing Ontology group - Terminologies/semantic alignment Governance group - Data Use Agreements/institutional alignment Evaluation group - Process, outcomes and usability evaluation

    11. Pandora�s box issues The risk of being successful� Business intelligence Scope and control Protecting the patients Protecting the partners Protecting the developers �Surfing� the project on the wave of emergent approaches

    12. Questions? nicka@u.washington.edu

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