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Caspase Cascade. TNFR. Fas. Calcium Channel. TNF. RAIDD. RAIDD. FADD. FADD. TRADD. TRADD. TRADD. Caspase1. Caspase9. Procaspase8. BAD. Caspase8. Caspase8. tBID. BID. CIAP. CIAP. F a s L. Caspase 3,6,7. SMAC/ DIABLO. TRAF2. RIP2. PAK1. JNK. RICK. NIK. DNA-PK. CytoC.
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Caspase Cascade TNFR Fas Calcium Channel TNF RAIDD RAIDD FADD FADD TRADD TRADD TRADD Caspase1 Caspase9 Procaspase8 BAD Caspase8 Caspase8 tBID BID CIAP CIAP FasL Caspase3,6,7 SMAC/DIABLO TRAF2 RIP2 PAK1 JNK RICK NIK DNA-PK CytoC CytoC D4-GDI Perforin Perforin Activated Tissue Transglutaminase APAF1 Calpain NF-kB GranzymeB Caspase2 Caspase2 Caspase2 Caspase10 PARP Rb Caspase12 ICADCleaved Lamin-B2 Lamin-A Lamin-B1 Lamin-A 2009 ProteinLounge.com Sphingo-myelinase Daxx GRB GRB Kinase ICAD CAD CAD Ca2+ Ca2+ C ER Stress Ceramide CRMA Cell Survival CLEAVAGE OF DEATH SUBSTRATES Apoptosis DNAFragmentation Apoptosis