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PULSE Lecture 1

PULSE Lecture 1. Introduction to Endocrinology. What the endocrine system is and its role in regulation of the human body (contrast endocrine system to exocrine system) in terms of temperature, blood sugar, calcium levels, etc.

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PULSE Lecture 1

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  1. PULSE Lecture 1 Introduction to Endocrinology

  2. What the endocrine system is and its role in regulation of the human body (contrast endocrine system to exocrine system) in terms of temperature, blood sugar, calcium levels, etc. • Organs of the endocrine system: ie. Pituitary, pineal gland, thymus, parathyroid, adrenal, thyroid gland, testis or ovary • That the endocrine system carries out regulation via hormones (they should know the types of hormonal signaling, ie. Autocrine, paracrine, intracrine, endocrine, exocrine) • Different classes of hormones (there are a variety of protein based and lipid/steroid based hormones) and how they act on a cell if they are protein based vs. steroid based due to hydrophobic vs hydrophilic properties • The concept of secondary messenger systems and amplification • Negative feedback and positive feedback Learning Objectives

  3. from the Greek hormao: “to excite, to arouse, to put in quick motion” from Greekἔνδον, endo, "within"; κρῑνω, krīnō, "to sift or to separate" Hormone Endocrinology

  4. Definition of an endocrine gland

  5. The Endocrine System

  6. Types of hormonal signaling

  7. Types of hormonal signaling

  8. Classes of Hormones

  9. Steroid vs. Non-Steroid Hormones and Their Mechanism of Action

  10. Hydrophilic v. Hydrophobic

  11. Steroid Hormones and Their Mechanism of Action

  12. Non-steroid or Protein-based and Their Mechanism of Action

  13. Endocrine Gland Effect of Target Organ Hormone Feedback loops Target Organ

  14. Decrease stimulus to insulin secretion Beta Cell of Pancreatic Islet High Glucose Endocrine Gland Effect of Target Organ Hormone Insulin Decrease in blood glucose Feedback loops Target Organ Skeletal Muscle: increase glucose uptake

  15. Decrease Stimulus to PTH Sectretion Parathyroid Gland Low Calcium Endocrine Gland Effect of Target Organ Hormone PTH Increase in Blood Calcium Feedback loops Target Organ Bone: To Increase Calcium Mobilization

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