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To Start. In 1918, Russia experienced revolution Bolshevik authorities shot Tsar Nicholas II, his family and 4 servants in the cellar of their home The family were told that they were to be photographed to prove they were alive and arranged themselves appropriately

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  1. To Start In 1918, Russia experienced revolution Bolshevik authorities shot Tsar Nicholas II, his family and 4 servants in the cellar of their home The family were told that they were to be photographed to prove they were alive and arranged themselves appropriately Gunmen then entered the room and begun shooting The bullets rebounded off jewels sown into the corsets of the female family members. Executioners tried to stab them with bayonets and then shot the in the head The story of the Romanov family is fascinating and gruesome, but what does it have to do with biology?!

  2. Learning Objectives • Describe the story of Alexsei Romanov • Explain the link between his story and genetics • Examine the inheritance patterns seen in the Royal families across Europe

  3. The House of Romanov Maria Romanov Tatiana Romanov Anastasia Romanov Alexandra Romanov Nicholas Romanov Alexsei Romanov Olga Romanov

  4. Alexei Romanov • Alexsei Romanov was born in 1904, the youngest Romanov child • He appeared healthy until the age of 6 when he began to bleed from his naval • Alexsei was diagnosed with a rare genetic disease called Haemophilia • His joints would fill with blood when he hurt himself causing him extreme pain • He almost died from a haephophilic attack when he was 8 as a result of a leg injury • He was shot twice at close range during the revolution and likely bleed to death. He was 13 years old.

  5. Genetic Inheritance of Haemophilia

  6. Punnett Squares • Punnet Squares are a way to work out the likelihood of certain inheritance patterns in the offspring of two known individuals

  7. Task 1 • Complete the sheet ‘Genetics and The Romanovs’

  8. Task 2 • Play ‘The Royal Blight’ Game • Each lab group will be given one of four members of the Victorian Royal Family, and will arrange marriages between their royal and one of twelve royals from other countries. • The hemophilia genotypes will be given for the royals, and the students will produce Punnett squares predicting the possible offspring from their marriage. • They will then roll a four-sided die to select one outcome, and the resultant prince or princess (F1 generation) will be “married” to another group’s prince or princess. • Complete the sheet ‘Genetic Counseling for the Royals’

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