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Differential Scanning Calorimetry

Differential Scanning Calorimetry. DPPC. 0 0 C for 3 days. Trapped kinetic states. Structure of lipid –head group and acyl chains Degree of hydration T, P, pH, ionic strength. Polymorphic Structure Depends:. DSC for DPPH as a function of water hydration. CHAIN LENGTH. DxPC. DxPC.

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Differential Scanning Calorimetry

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  1. Differential Scanning Calorimetry DPPC 00C for 3 days Trapped kinetic states

  2. Structure of lipid –head group and acyl chains • Degree of hydration • T, P, pH, ionic strength Polymorphic Structure Depends:

  3. DSC for DPPH as a function of water hydration CHAIN LENGTH

  4. DxPC DxPC Ripple to liquid = solid Gel to ripple = open X=2 gives straightest line. Concept : Carbonyl and terminal methyl do not stabilize transition and that the gel liquid is dominated by chain melting Extrapolates to 151oC polymethylene (138oC mp) Extrapolates to n = 4.8 at 0K, implies you need at least 5 carbon atoms in chain for an organized assembled structure

  5. DxPC Need at least 8C to have lamellar structures, smaller acyl chains form micelles

  6. POPC vs OPPC

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