Cancer Prevention Study – 3

1. Cancer Prevention Study – 3 Gainesville, Georgia Enrollment

2. “Everyone knows that cigarette smoking causes lung cancer. Few realize that it took three years, 22,000 volunteers, and 188,000 study participants to prove it.” - Meghan Murphy, The Greeley Tribune

3. American Cancer Society Previous Follow-Up Studies CPS-I 1,000,000 Both 68,000 25 1959-72 Smoking, obesity CPS-II 1,200,000 Both 77,000 50 1982- Multiple Hammond-Horn 188,000 Men 22,000 9 1952-55 Smoking Participants Sex Volunteers States Years Research Emphasis

4. Major Contributions to Public Health • 21 U.S. Surgeon General Reports on Smoking & Cancer. • Confirm relationship of 2nd hand smoke with lung cancer & heart disease, helping to motivate smoke-free laws. • Found that low tar/nicotine cigarettes don’t reduce lung cancer risk. • First epidemiological study that overweight/obesity shortens longevity. • Landmark paper linking obesity to increased death rates from at least ten cancer sites, including colon and post-menopausal breast cancer. • First US epidemiologic study showing sitting time shortens longevity. • Major contributions to IARC Monographs, WCRF/AICR Reports on PA, nutrition and obesity • Discovery of the link between aspirin use and lower risk of colon cancer. • Air pollution (small particulates/ozone) increase death rates from heart and lung conditions; motivate the EPA to propose stringent limits on air pollution.

5. Cancer Prevention Study – 3 CPS-I 1959-72 1,000,000 Both 68,000 25 Mortality Smoking, obesity CPS-II 1982- 1,200,000 Both 77,000 50 Mortality (& incidence) Multiple CPS-3 2006- 300,000 Both 25,000 35 Mortality & incidence Multiple Years Participants Sex Volunteers States Cancer endpoints Research Emphases Hammond-Horn 1952-55 188,000 Men 22,000 9 Mortality Smoking

6. Purpose of CPS-3 Better understand the factors (lifestyle, environmental, genetic) that cause or prevent cancer Ultimately, to help eliminate cancer as a major health concern for this and future generations

7. CPS-3 Objectives Enroll a diverse group of at least 300,000 men and women Willing to make a long-term commitment to the study by completing a survey periodically 30-65 years of age Never been diagnosed with cancer Recruitment goals At least 25% overall minority participation Geographic diversity Blood sample on all study participants at enrollment

8. What is involved in being a study participant? • Enrollment • Registering for an appointment online or by phone • At home, comprehensive Baseline Survey • At Northeast Georgia Medical Center, complete informed consent, survey, waist measurement, and small blood sample drawn • Follow-up in the future • Repeat surveys periodically to update exposure information and health outcomes

9. CPS-3 Gainesville Enrollment Details April 23rd-24th, 2013 Northeast Georgia Medical Center www.cps3Gainesville.org or call 1-888-604-5888 *Enrollment will take place in the old Surgery Pavilion, between the North & South Towers Ways to get involved: • Consider enrolling, if you are eligible • Be a CPS-3 advocate – share the opportunity with your circles

10. What Motivated You To Join CPS-3? *Note: Participants could mark up to 3 methods.

11. Recruitment, How-to • Your role • Inform • Educate • Answer questions • Provide website for appointment scheduling www.cps3gainesville.org

12. Recruitment, What to Do • Personal outreach • TALK about opportunity • Explain study, eligibility, importance • Provide website for appointment scheduling www.cps3gainesville.org • SHARE the opportunity via e-mail, phone, or however possible • Ask me for promotional material • Encourage those you know to help spread the word • Language about the study (enrollment process, etc.) must be used as-is (cut and paste) but you can add in your personal story.

13. What’s Next? • Share this important opportunity • Make the personal asks • Enroll yourself! www.cps3gainesville.org

14. Questions?

15. THANK YOU!