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BPG binds in the cavity between the -chains, making electrostatic interactions BPG cannot bind to the oxy form, thus functions by stabilizing the deoxy form. The decrease in oxygen affinity is explained by stabilization of deoxy-Hb.
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BPG binds in the cavity between the -chains, making electrostatic interactions BPG cannot bind to the oxy form, thus functions by stabilizing the deoxy form. The decrease in oxygen affinity is explained by stabilization of deoxy-Hb