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Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted Imaging

Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted Imaging. Lakshman Gollapalli. Huntington’s Disease (HD). Huntington’s disease is a dominantly inherited degenerative disease of the CNS The pathological features include atrophy of the CN, chorea and neuronal loss

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Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted Imaging

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  1. Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted Imaging Lakshman Gollapalli

  2. Huntington’s Disease (HD) • Huntington’s disease is a dominantly inherited degenerative disease of the CNS • The pathological features include atrophy of the CN, chorea and neuronal loss • Changes in caudate volume have been documented in MRI studies

  3. Susceptibility Weighted Imaging (SWI) • SWI exploits the magnetic susceptibility effects generated by local field inhomogeneities • Signals from tissues with different susceptibilities compared to their neighboring tissue will become out of phase • New type of contrast

  4. Results

  5. Using SWI for noninvasive tracking of SVZ labeled cells in Rat subjected to stroke • SVZ cells labeled with iron particles were injected in Rat subjected to stroke • Using SWI as a means to track the cell migration and identify angiogenesis

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