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Genetics. I. Introduction. A. History. 1. C . Darwin & A . Wallace blending. 2. G . Mendel & F . Unger mixing. 3. W . Sutton Chromosomal theory of Inheritance. 4. T . Morgan Genes & Chromosomes plus linkage groups. 5. A . Sturtevant genetic mapping.
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Genetics I.Introduction A.History
1. C.Darwin& A.Wallaceblending 2. G.Mendel& F.Ungermixing 3. W. SuttonChromosomal theory of Inheritance 4. T. Morgan Genes & Chromosomes plus linkage groups
5. A.Sturtevantgenetic mapping 6. F.Griffithhereditary molecule 7. O. Avery etal. DNA hereditary molecule 8. B. McKlintock Transposons
9. W.Fierssequenced viral gene 10. A.JeffreysDNA finger printing 11. 1995Viral DNA sequenced 12. 1996 yeast DNA sequenced 13. 1998 round worm DNA sequenced 14. 2003 human DNA sequenced
II.Mendelian A.Experimental Design 1.Monohybrid Cross
a. Definition b. Terms i.Self vs.Cross Fertilization ii.Traits vs.Characteristics
c. Process Figure 14.2
c. Process Figure 14.3
Figure 14.4 d. Principle traits are paired and sorted
d. Principle traits are paired and sorted Figure 14.5
i.Gene versus Allele e. Terms iii.Dominance versus Recessive iv.Genotype versus Phenotype ii. Homozygous versus Heterozygous
f. Testcross Figure 14.7
a. Definition b. Process Start by figuring out how many andtype of gametes Figure 14.8
Practice Dihybrid Heterozygous cross = AaBb X AaBb Gametes AaBb = AB, Ab, aB, & ab for both Phenotypic ratio= 9:3:3:1, Genotypic ratio= 1:1:2:2:4:2:2:1:1 Dihybrid Heterozygous cross Homozygous Dominant = AaBb X AABB Gametes AaBb = AB, Ab, aB, & ab; AABB= AB only Phenotypic ratio = all dominant, Genotypic ratio = 1:1:1:1 c. Principle Each pair of alleles and chromosomessort independently into gametes.
III.Variation on Mendel A.Dominance
1. Complete 2. Co-dominance AA aa Aa
3. Incomplete dominance Figure 14.10
2. Pleitrophy 3. Penetrance
2. Polygenic Figure 14.11
2. Polygenic Figure 14.12
IV.Classical Genetics A.History
1. R.Punnet& W.Bateson??? Figure 14.9
2. T. Morgan Genes & Chromosomes, Karyotyping, plus linkage groups a. Drosophila melangastor WHY? Figure 15.3
b. Genetic Recombination Figure 15.5
3. A. Sturtevant Genetic Mapping Based on frequency of expression of traits showing together Figure 15.6
3. A. Sturtevant Genetic Mapping Based on frequency of expression of traits showing together Figure 15.7
3. A. Sturtevant Genetic Mapping Based on frequency of expression of traits showing together Figure 15.8
1. Basis of SEX Figure 15.9
1. SEX linked inheritance Figure 15.9
a. Barr Bodies Figure 15.11
V.Detection of Problems A.Techniques
1. Karyotyping 2. Amniocentesis == Cellular and Chemical Analysis Figure 14.17
3. Ultrasound 4. Chorionic Villi Sampling == Cellular and Chemical Analysis Figure 14.17
6. Pedigree Analysis Figure 14.14